tag:blogger.com,1999:blog-20672118313388775332024-02-19T08:32:52.859+00:00Stop Cancer UK Cancer Prevention - Nutrition, Diet and Lifestyle.Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.comBlogger43125tag:blogger.com,1999:blog-2067211831338877533.post-17457557897483485832018-06-26T10:28:00.000+01:002018-06-26T10:30:53.493+01:0043. Cannabis and Cannabinoids in future Cancer Treatment<div dir="ltr" style="text-align: left;" trbidi="on">
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<b style="mso-bidi-font-weight: normal;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgBVpxyhWMTnHLZHvBzCTKr4BV9xvBLUcfuh9ToSrz_ebz185f_e3Vl3uw5_HdQMbo9sGtZUpB03pZfSmw7jAYTjBCicXdrd-8YxcNJ44DeiB9CXZ_l_fNDW9ay6lRRp6M0on_2KlvztYE/s1600/Cannabis-sativa-plant.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="457" data-original-width="610" height="478" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgBVpxyhWMTnHLZHvBzCTKr4BV9xvBLUcfuh9ToSrz_ebz185f_e3Vl3uw5_HdQMbo9sGtZUpB03pZfSmw7jAYTjBCicXdrd-8YxcNJ44DeiB9CXZ_l_fNDW9ay6lRRp6M0on_2KlvztYE/s640/Cannabis-sativa-plant.jpg" width="640" /></a></b></div>
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<span lang="EN-US" style="font-size: 18pt;"><i>Photo: Wikimedia</i></span></div>
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<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><br /></span></b></div>
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<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;">Cannabinoids THS and CBD<o:p></o:p></span></b></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>The
harrowing story of young Billy Caldwell’s epilepsy and UK Home Secretary’s subsequent
decision to review the official use of Cannabis for medicinal use, (19 June),
has highlighted the potential medicinal properties of the Cannabinoids THS and
CBD extracted from the Marijuana plant or synthesized. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>In
the event, Oxford University’s 16 March announcement of a £10M medical Marijuana
Research programme sponsored by Kingsley Capital Partners through their new
company Oxford Cannabinoid Technologies, (OCT), was both timely and prescient. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>CBD
is thought to give pain relief and reduce anxiety while THS gives the ‘high’
that recreational Cannabis users seek. It is this ‘high’ that has resulted in Cannabis
being labeled a ‘controlled’ narcotic drug in UK and classified by the Misuse
of Drugs Act, 1971.<span style="mso-spacerun: yes;"> </span>Additionally the Misuse
of Drugs Regulations Act of 2001 placed Cannabis in the category for substances
with no medicinal value. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span style="font-size: 18.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman";"><span style="mso-spacerun: yes;"> </span>Marijuana has been cultivated
since Neolithic times and Cannabis used in folk medicine for at least 3,000
years. The earliest written reference to Cannabis as a healing agent was in the
15<sup>th</sup> century BCE Chinese Pharmacopeia Rh-Ya. More recently in modern
times during the 19<sup>th</sup> and first decade of the 20<sup>th</sup>
century Cannabis was prescribed in USA and UK for a number of ailments.<span style="mso-spacerun: yes;"> </span>It was first labelled as a dangerous drug by
Massachusetts in 1911 and thereafter elsewhere in USA. It was added to the UK’s
Dangerous Drugs Act in 1928.<span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span style="font-size: 18.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman";"><span style="mso-spacerun: yes;"> </span>It was not until 1996, when
California became the first US State to re-legalise Marijuana for medical use,
that cannabis began its long journey back as a responsible treatment therapy
for cancer, AIDS, and other diseases and disorders.</span><span lang="EN-US" style="font-size: 18.0pt;"><o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>As
a consequence of marijuana’s illegal narcotic drug status throughout most of
the 20<sup>th</sup> century, both scientific and clinical research into the
medicinal benefits of Cannabinoids was severely restricted.<span style="mso-spacerun: yes;"> </span>However, recent and now accelerating trends
in Cannabis legislation have at last made it possible for scientific and
clinical researchers to study the medical properties of Cannabinoids as possible
antitumour agents as well as their expected therapeutic treatment applications
in cancer and other diseases and disorders. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>The
Oxford research project will focus on two of the 100 or so Marijuana Cannabinoids
for their anticancer and therapeutic potential in treatment of cancer, </span><span style="font-size: 18.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman";">inflammatory diseases, pain management and neurological disorders</span><span lang="EN-US" style="font-size: 18.0pt;">. </span><span style="font-family: "times new roman"; font-size: 18.0pt;"><o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>In
USA the Federal Drugs Administration, (FDA), approved two synthetic cannabinoid
drugs (dronabinol and nabilone) for the treatment of nausea and vomiting induced
by chemotherapy in those cancer patients who have not responded to standard
therapy. Both are available in UK on adult prescription only. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<br /></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;">Inhaled
Cannabis<o:p></o:p></span></b></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;"> </span>While
there have been a few uncontrolled clinical trials on the use of inhaled Cannabis
in cancer patients, the data has been insufficient to provide any acceptable assessment
of its beneficial use in chemotherapy induced nausea and vomiting, (N/V). </span><span style="background: #fffffb; color: #2e2e2e; font-size: 18.0pt;">There
are however valid concerns about the adverse </span><span lang="EN-US"><a href="https://www.cancer.gov/Common/PopUps/popDefinition.aspx?id=45852&version=healthprofessional&language=English&dictionary=Cancer.gov"><span lang="EN-US" style="background: #fffffb; border: none 1.0pt; color: #2e2e2e; font-size: 18.0pt; padding: 0cm; text-decoration: none;"><span lang="EN-US">pulmonary</span></span></a></span><span style="background: #fffffb; color: #2e2e2e; font-size: 18.0pt;"> effects
of </span><span lang="EN-US"><a href="https://www.cancer.gov/Common/PopUps/popDefinition.aspx?id=44600&version=healthprofessional&language=English&dictionary=Cancer.gov"><span lang="EN-US" style="background: #fffffb; border: none 1.0pt; color: #2e2e2e; font-size: 18.0pt; padding: 0cm; text-decoration: none;"><span lang="EN-US">inhaled</span></span></a></span><span style="background: #fffffb; color: #2e2e2e; font-size: 18.0pt;"> <span style="border: none windowtext 1.0pt; mso-bidi-font-style: italic; mso-border-alt: none windowtext 0cm; padding: 0cm;">Cannabis</span> since <span style="border: none windowtext 1.0pt; mso-bidi-font-style: italic; mso-border-alt: none windowtext 0cm; padding: 0cm;">Cannabis</span> smoke contains
many of the same components as </span><span lang="EN-US"><a href="https://www.cancer.gov/Common/PopUps/popDefinition.aspx?id=439432&version=healthprofessional&language=English&dictionary=Cancer.gov"><span lang="EN-US" style="background: #fffffb; border: none 1.0pt; color: #2e2e2e; font-size: 18.0pt; padding: 0cm; text-decoration: none;"><span lang="EN-US">tobacco</span></span></a></span><span style="background: #fffffb; color: #2e2e2e; font-size: 18.0pt;"> smoke
which is a prime cause of lung cancer.</span><span lang="EN-US" style="font-size: 18.0pt;"><o:p></o:p></span></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 18.0pt;"><span style="mso-spacerun: yes;">
</span><span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;">Further Reading<o:p></o:p></span></b></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="http://procon.org/">ProCon.org</a></span></b></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 18.0pt;">History of
Marijuana as Medicine – 2900BCE to Present.</span></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="https://www.ancient-origins.net/history/cannabis-journey-through-ages-003084">Ancient Origins</a><o:p></o:p></span></b></div>
<div class="MsoNormal">
<span style="font-size: 18pt;">Cannabis: A
Journey Through the Ages</span></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="http://pubmed./">PubMed.</a></span></b></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 18.0pt;">Cannabis:
Pharmacology and toxicology. .</span></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="http://www.ox.ac.uk/news/2017-03-15-cannabinoid-biomedicine-research-programme-launched">Oxford University</a></span></b></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 18.0pt;">New £10M cannabinoid
biomedicine research programme launched.</span></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="http://oxcantech.com/potential/">Oxford Cannabinoid Technology</a><o:p></o:p></span></b></div>
<div class="MsoNormal">
<span style="font-size: 18pt;">Clinical Potential
of the Cannabis plant.</span></div>
<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 18.0pt;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26923810">Pubmed</a><o:p></o:p></span></b></div>
<div class="MsoNormal">
<span style="font-size: 18pt;">Nabilone for
treatment of chemotherapy induced nausea and vomiting.</span></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 18.0pt;">. <o:p></o:p></span></div>
<!--EndFragment--><br /></div>
Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-7144133366048959822018-06-13T19:05:00.000+01:002018-06-13T19:09:48.395+01:0042. Breast Cancer Good News!<div dir="ltr" style="text-align: left;" trbidi="on">
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
<br /></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjLoae1b7b-_1r4TbvoKcpiaY_Vl3xabqHtMpBBqYWyr8LljR6Jl-3Vkf0VOdA_ykkqym4RF9lYlwECJXbKUzP1ZR_d9p3_JApYZxXBsx4PYXkbTRgxCpuwv5VJQ5frDL5LvHguwwLzqYo/s1600/breastcancer.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="300" data-original-width="670" height="286" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjLoae1b7b-_1r4TbvoKcpiaY_Vl3xabqHtMpBBqYWyr8LljR6Jl-3Vkf0VOdA_ykkqym4RF9lYlwECJXbKUzP1ZR_d9p3_JApYZxXBsx4PYXkbTRgxCpuwv5VJQ5frDL5LvHguwwLzqYo/s640/breastcancer.jpg" width="640" /></a></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: center;">
<i>Illustration: American Heart Association</i></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
The majority of patients with the most common type of breast cancer do not benefit from chemotherapy after surgery according to a comprehensive study.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
A decade long multi-center study by the <a href="http://ecog-acrin.org/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">ECOG-ACRIN</a> Research Group, involving 10,273 women with early-stage cancer at 1,182 treatment sites across USA, Australia, Canada, Ireland, New Zealand and Peru, showed conclusively that chemotherapy was unnecessary in 70% of cases.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
The Stage-3 Trial findings were published in the <a href="https://www.nejm.org/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">New England Journal of Medicine</a> last week following the trial leader’s presentation to the <a href="https://www.asco.org/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">American Society of Clinical Oncology (ASCO)</a> annual meeting.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
Unlike many published clinical trial results which require many years of further study before findings are confirmed and validated, this trial’s results will have an immediate impact on global treatment practice for early-stage breast cancer.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
Dr. Alistair Ring, a consultant oncologist at the <a href="https://www.royalmarsden.nhs.uk/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">Royal Marsden NHS Hospital, London</a>, was upbeat about the potentially immediate impact on breast cancer treatment in the NHS. “I think this is a fundamental change in the way we treat women with early-stage breast cancer and will lead to a considerable number of women no longer needing to have chemotherapy.”</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
Up to 5,000 women in UK could now avoid the harrowing side effects from the toxic drugs used in chemotherapy, if this life-changing refinement of early-stage breast cancer treatment is followed across the <a href="https://www.nhs.uk/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">NHS</a>.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
Until now, post-operative treatment included hormone therapy plus chemotherapy for women diagnosed with early-stage HR-positive, HER2-negative, axillary lymph node-negative breast cancer. This therapy combination was administered to these patients to inhibit cancer recurrence. However the trial showed that invasive disease-free survival after treatment was almost statistically the same, whether patients had the combination therapy or hormone therapy alone.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
There is an additional bonus this refined post-operative cancer treatment of hormone-only therapy will have for healthcare systems around the world: lower costs!</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
The <a href="https://www.nhs.uk/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">NHS</a> is struggling with the spiralling costs of cancer drugs used in chemotherapy. These drug costs inhibit the ability of an underfunded <a href="https://www.nhs.uk/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">NHS</a> to adequately invest in other cancer services.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px; text-align: justify;">
<strong>Further Reading</strong></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1804710?query=recirc_mostViewed_railB_article"><strong> </strong><strong>New England Journal of Medicine</strong></a></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
<strong><a href="https://www.cancer.gov/news-events/press-releases/2018/tailorx-breast-cancer-chemotherapy?cid=eb_govdel">National Cancer Institute Press Release</a></strong></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
TAILORx Trial result</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
<strong><a href="http://ecog-acrin.org/about-us/membership">ECOG-ACRIN Cancer Research Group</a></strong></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
Multi-national network of participating institutions.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
<a href="https://www.cbsnews.com/news/many-breast-cancer-patients-can-safely-skip-chemotherapy-major-study-finds/"><strong> </strong><strong>CBS News</strong></a></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
Many breast cancer patients can safely skip chemotherapy, study finds.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
<strong><a href="https://www.bbc.co.uk/news/health-38769625">BBC News</a></strong></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; margin-bottom: 25px;">
Cancer drugs price rise ‘costing NHS millions’</div>
</div>
Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-90318231679027174832018-06-07T14:15:00.001+01:002018-06-07T14:40:08.870+01:0041. Immunotherapy future for breast and other cancers<div dir="ltr" style="text-align: left;" trbidi="on">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4xvxezYW92DR8js6xdUXXzsFP6_tqsP0DwJl138E0tHkNzCN7z3ufnS7I8W7ncvRRsJs_TkRX2FlsiM9O16UoP_yR95k0tLgg-p8BVLjwj3Vw90oj7atPXBGrIc7mS-XtpUfxLsq7Qwo/s1600/20180604-rose.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="806" data-original-width="1157" height="444" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4xvxezYW92DR8js6xdUXXzsFP6_tqsP0DwJl138E0tHkNzCN7z3ufnS7I8W7ncvRRsJs_TkRX2FlsiM9O16UoP_yR95k0tLgg-p8BVLjwj3Vw90oj7atPXBGrIc7mS-XtpUfxLsq7Qwo/s640/20180604-rose.jpg" width="640" /></a></div>
<div style="text-align: center;">
<br /></div>
<br />
<div style="background-color: white; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<span style="color: #4a4a4a;">Th</span>e <span style="outline-color: initial; outline-width: initial; transition: color 0.4s;">US National Cancer Institute’s, ((NCI),</span><span style="color: #4a4a4a;"> development of a novel approach to immunotherapy, reported in the June issue of Nature Medicine, has been given wide coverage in the British press. It is an important step forward in our understanding of cancer mutation and treatment.</span></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
The complex trial approach was in fact a modified form of adoptive cell transfer, (ACT), which has already been effectively used in in skin cancer treatment trials.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
The treatment trial on a patient with late-stage breast cancer led to the complete cancer regression in the patient who had been unresponsive to all other treatments. All of the patient’s cancer, which had spread to other parts of her body, disappeared after the treatments and has not returned more than 22 months later.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
This was an innovative experimental approach for one very lucky 52-year-old patient who had not responded to hormonal and chemotherapy, and whose condition had deteriorated to a point that she was planning her death after the cancer had spread to her lungs and liver.</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
Extensive and time-consuming multi-centre trials must now be undertaken to prove the treatment’s efficacy before it can be made routinely available to treat late-stage breast cancer patients.</div>
<div style="background-color: white; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<span style="color: #4a4a4a;">“This is an illustrative case report that highlights, once again, the power of immunotherapy,” commented Tom Misteli, Director of </span>NCI’s<span style="color: #4a4a4a;"> Centre of Cancer Research, </span><span style="color: black;"><span style="outline-color: initial; outline-width: initial; transition: color 0.4s;">(CCR) at Bethesda</span>.</span><span style="color: #4a4a4a;"> “If confirmed in a larger study, it promises to further extend the reach of this T-cell therapy to a broader spectrum of cancers.”</span></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<a href="https://ccr.cancer.gov/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">CCR’s</a> Dr. Steven Rosenburg, the clinical trial leader, commented on the broad potential of this experimental trial approach: “Because this new approach to immunotherapy is dependent on mutations, not on cancer type, it is in a sense a blueprint we can use for the treatment of many types of cancer.”</div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<br /></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<strong>Further Reading</strong></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<strong> </strong><a href="https://www.nih.gov/news-events/news-releases/new-approach-immunotherapy-leads-complete-response-breast-cancer-patient-unresponsive-other-treatments" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank"><strong>US National Institute of Health</strong></a></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<i><span style="font-size: x-small;"><a href="https://www.nih.gov/news-events/news-releases/new-approach-immunotherapy-leads-complete-response-breast-cancer-patient-unresponsive-other-treatments">New approach to immunotherapy.</a></span></i></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<a href="https://www.cbsnews.com/news/immunotherapy-treatment-saves-life-of-woman-with-late-stage-breast-cancer/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank"><strong>CBS. Jonathan LaPook</strong></a></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<i><span style="font-size: x-small;"><a href="https://www.cbsnews.com/news/immunotherapy-treatment-saves-life-of-woman-with-late-stage-breast-cancer/">Groundbreaking treatment saves life of woman with late-stage breast cancer.</a></span></i></div>
<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; margin-bottom: 25px; text-align: justify;">
<i><span style="font-size: x-small;">Files 07.06.2018. <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></span></i></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0United Kingdom55.378051 -3.4359729999999912.203021 -86.05316049999999 90 79.18121450000001tag:blogger.com,1999:blog-2067211831338877533.post-65858351600103100232018-06-07T14:00:00.002+01:002018-06-07T14:00:28.010+01:0040. Blood tests show promise as early cancer screening process<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="color: #4a4a4a;">Studies of a blood test for 10 different types of cancers show promise as an early cancer screening process before patients show symptoms, Dr Eric Klein from the Taussig Cancer Institute of Cleveland, USA, told members at the annual conference of the </span><span style="outline-color: initial; outline-offset: -2px; outline-width: initial; transition: color 0.4s;"><span style="color: black;">American Society of Clinical Oncologists, (ASCO)</span><span style="color: #4a4a4a;">,</span></span><span style="color: #4a4a4a;"> in Chicago last week.</span></div>
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The blood test, called a liquid biopsy, screens for cancer by detecting tiny bits of DNA released by cancer cells into blood. The liquid biopsy technology was initially used to monitor patients after they receive treatment for an advanced cancer to evaluate their treatment’s progress or detect a recurrence through increased cancer cell DNA.</div>
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<span style="color: #4a4a4a;">In recently completed studies of blood biopsy tests at Dr Klein’s </span><span style="color: black;">Cleveland Centre and at Stanford University</span><span style="color: #4a4a4a;">, clinicians scrutinised the cases of more than 1,600 people, 749 of whom were cancer-free at the time of the study, and 878 of whom had been newly diagnosed with a cancer. Liquid biopsies correctly found cancer cell DNA in 80% of the 878 patients in tests for pancreatic, ovarian, liver and gallbladder cancers. The tests were less accurate with lymphoma, myeloma, bowel, lung, head and neck cancers with a low correct diagnosis ranging from only 56% to 77%.</span></div>
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Although promising, there is obviously a long way to go in research to achieve the desired positive or negative predictive values with liquid biopsies before we can safely implement such tests in any national screening programme. To illustrate, globally ovarian cancer has an annual incidence of approximately 12 cases per annum per 100,000 women. If the new test has only an 80% chance of detecting this disease, this would translate to a failure (false negative) to detect 1 in 5 of these cancers. Furthermore, if the test has a false positive rate of just 1%, this would mean incorrectly diagnosing 1000 women as cancer positive in order to detect less than 12 actual cancers.</div>
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So there is obviously considerably more research needed to clinically develop blood tests to a point where they can accurately detect a cancer. However, following on-going studies presented by Dr Vogelstein of John Hopkins School of Medicine to the conference in 2017, and by Dr Klein last week, further research could ultimately lead to the availability of an accurate universal blood test screening for cancer, enabling doctors to accurately detect a cancer in patients at what is presently an undetectable early stage.</div>
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“This is potentially the Holy Grail of cancer research, to find cancers that are currently hard to cure at an earlier stage when they are easier to cure,” said Dr Klein, lead author of the Taussig Centre study. “Potentially this test could be used for everybody. It is several steps away and more research is needed, but it could be given to healthy adults of a certain age, such as those over 40, to see if they have early signs of cancer. We hope this test could save many lives.”</div>
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<span style="color: #4a4a4a;">As Dr Bert Vogelstein of </span><span style="outline-color: initial; outline-width: initial; transition: color 0.4s;">John Hopkins Kimmel Cancer Centre</span> <span style="color: #4a4a4a;">pointed out at last years </span>ASCO<span style="color: #4a4a4a;"> conference: “It’s fair to say that if you could detect all cancers while they are still localised, you could diminish cancer deaths by 90%.”</span></div>
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Studies at John Hopkins have indicated that while cancers of liver, stomach, pancreatic, ovarian, oesophagus, colon, lung and breast can be detected from cancer tumour DNA in the blood, not all tumour types can be accurately detected in this way. Their studies continue with gene-based cancer tests that work using bodily fluids and secretions as well as blood.</div>
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An accurate liquid biopsy cancer screening in the UK and consequent early treatment for cancer positives would save thousands of lives and millions of pounds. But the NHS is presently overwhelmed, understaffed and underfunded and, thanks to the ever-growing pressure of rising demand, it is not coping with acute cases, let alone belated or cancelled treatment and diagnostic procedures. And this does not include the potential cost of funding and operating universal blood tests for those people who don’t actually realise that they are sickening with a previously undetected cancer.</div>
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Perhaps, by the time accurate liquid biopsy tests envisaged by Drs Vogelstein and Klein have been perfected for cancer detection, we shall have an adequately funded and fully staffed NHS that can make them universally available to those over 40.</div>
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Extensive time-consuming clinical research into liquid biopsies is underway in USA and the University of Manchester’s Research Centre in UK to find that Holy Grail of accurate comprehensive early stage cancer detection by means other than X-rays, colonoscopy or pap smears. However Press headlines about cancer detection progress rarely mention the research timescales and cost. These studies take considerable time and money, as will the additional multi-centre research over the next five or ten years to evaluate and confirm a genetic blood test as fit for purpose, before any universal screening test can be implemented.</div>
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We need to keep funding this exciting research to advance the science of liquid biopsies. The research has come a long way in the past five years, but we still have a long way to go.</div>
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<b>Further Reading</b></div>
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<b>ASCO </b>- <a href="https://www.asco.org/research-progress/reports-studies/clinical-cancer-advances-2018#/advance-year-cancer-immunotherapy"><span style="font-size: x-small;"><i>Clinical Cancer Advances 2018.</i></span></a></div>
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<b>Health Day</b> - <a href="https://consumer.healthday.com/cancer-information-5/mis-cancer-news-102/could-a-blood-test-spot-lung-cancer-early-734379.html"><span style="font-size: x-small;"><i>Could a blood test spot lung cancer early?</i></span></a></div>
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<a href="https://newsroom.clevelandclinic.org/?ga=2.214432279.1294138397.1527874558-725613676.1527874558" rel="noopener" style="outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank"><b><span style="color: black;">Taussig Cancer Institute</span></b> - </a><span style="color: #3783c1; font-size: x-small;"><span style="outline-color: initial; outline-width: initial; transition: color 0.4s;"><a href="https://newsroom.clevelandclinic.org/2018/06/01/cleveland-clinic-cancer-center-experts-present-data-at-2018-asco-annual-meeting/"><i>Cleveland Cancer Centre Experts present data at 2018 ASCO annual meeting.</i></a></span></span></div>
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<b>John Hopkins School of Medicine</b> - <a href="https://cancer-matters.blogs.hopkinsmedicine.org/2018/03/23/seek-and-you-may-find-cancer/"><i><span style="font-size: x-small;">Two new screening tests that have promise to detect cancer at an early and curable stage.</span></i></a></div>
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<b>University of Manchester</b> - <i><span style="font-size: x-small;"><a href="https://www.manchester.ac.uk/research/beacons/cancer/">The University of Manchester’s approach to Cancer Research</a></span></i></div>
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<i><span style="font-size: x-small;">Filed 006.2018. <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></span></i></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-9977086025902693742018-06-07T13:36:00.000+01:002018-06-07T13:36:21.555+01:0039. Be SunSmart this Summer!<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="font-size: x-small;">Photo: Noosa, Australia</span></i></div>
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After a long winter, the prospect of a sunshine holiday looms large in our minds. There are however risk factors in acquiring that so-called ‘healthy tan’ from sunbathing. Over-exposure to sunlight radiation can cause three skin cancers that can kill; (malignant melanoma, squamous, or basal cell carcinoma).</div>
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To quote the Cancer Council of Australia website, “A tan is not a sign of good health or wellbeing, despite many Australians referring to a ‘healthy tan’. Almost half of Australian adults still hold the misguided belief that a tan looks healthy. Tanning is a sign that you have been exposed to enough UV radiation (from the sun or solarium) to damage your skin. This will eventually cause loss of elasticity (wrinkles), sagging, yellowish discolouration and even brown patches to appear on your skin. Worst of all, it increases your risk of skin cancer.</div>
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In the UK at least 100,000 new cases of skin cancer occur each year, and the numbers are growing. The prime cause is UV exposure from sunlight.</div>
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The sun gives off ultra-violet (UV) radiation. This radiation is an invisible killer that you can’t see or feel. Over-exposure to UV causes early aging of the skin and consequent skin damage that can lead to skin cancer. It can also cause problems with the eyes and the immune system.</div>
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Avoiding sunburns and intermittent high-intensity sun exposure (especially in children, teens, and young adults) reduces the chances of getting skin cancer. Babies and young children can easily get sunburnt, which can result in the potential for a skin cancer in later life.</div>
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The US National Cancer Institute, (NCI), recommend that people of all ages and skin tones should limit the amount of time they spend in the sun, especially between mid-morning and late afternoon, (10am – 4pm when), and avoid other sources of UV radiation, such as tanning beds.</div>
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UV radiation is reflected by sand, water, snow, ice and pavement. It can go through windshields, windows and even clouds.</div>
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Even though skin cancers are more common among people with a light skin tone, people of all skin tones can develop skin cancer, including those with dark skin.</div>
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The NCI, British Skin Foundation and the Australian Cancer Council offer tips to be sun smart and protect your skin from UV radiation.</div>
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<li style="line-height: 22px; text-align: justify;">Wear a hat with a wide brim all around that shades your face, neck, and ears. Baseball caps and some sun visors protect only parts of your skin.</li>
<li style="line-height: 22px; text-align: justify;">Wear sunglasses that block UV radiation to protect the skin around your eyes.</li>
<li style="line-height: 22px; text-align: justify;">Wear long sleeves and long pants. Tightly woven, dark fabrics are best. Some fabrics are rated with an ultraviolet protection factor (UPF). The higher the rating, the greater the protection from sunlight.</li>
<li style="line-height: 22px; text-align: justify;">The British Skin Foundation and Australian Cancer Council recommend that you use a sunscreen with a sun protection factor, (SPF), of least 30. Apply the product’s recommended amount to uncovered skin preferably 30 minutes before going outside, and apply again every two hours, or after swimming or sweating.</li>
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<strong>Further Reading</strong></div>
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<strong>British Skin Foundation</strong></div>
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<span style="font-weight: normal;"><span style="font-size: small;"><em><a href="http://www.britishskinfoundation.org.uk/SkinInformation/AtoZofSkindisease/Melanoma.aspx">Melanoma</a></em><em><br /></em></span></span></h3>
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<span style="font-weight: normal;"><span style="font-size: small;"><em><a href="http://www.britishskinfoundation.org.uk/SkinInformation/AtoZofSkindisease/BasalCellCarcinoma.aspx">Basal Cell Carcinoma</a></em><em><br /></em></span></span></h3>
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<span style="font-weight: normal;"><span style="font-size: small;"><em><a href="http://www.britishskinfoundation.org.uk/SkinInformation/AtoZofSkindisease/SquamousCellCarcinoma.aspx">Squamous Cell Carcinoma</a></em></span></span></h3>
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<strong style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;"><a href="https://www.cancer.org.au/preventing-cancer/sun-protection/preventing-skin-cancer/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">Australian Cancer Council</a> </strong></div>
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<a href="https://www.cancer.org.au/preventing-cancer/sun-protection/preventing-skin-cancer/"><i>Skin Cancer Prevention</i></a></div>
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<strong>US National Cancer Institute </strong></div>
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<a href="https://www.cancer.gov/news-events/cancer-currents-blog/2018/fda-dabrafenib-trametinib-melanoma-thyroid"><i>FDA approval for drug combination to treat advanced melanoma</i></a></div>
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<i> Filed 01.06.2018. <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></i></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-89610536431342388692018-06-07T13:12:00.000+01:002018-06-07T13:12:20.313+01:0038. Exercise as cancer treatment and prevention<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background-color: white; color: #4a4a4a; font-family: Times, "Times New Roman", serif;">Exercise is an essential component of successful Cancer treatment according to the Clinical Oncology Society of Australia, (COSA) latest Position Statement, (18 May). It highlights the crucial exercise role in Cancer Care as adjunct therapy alongside surgery, chemotherapy or radiation.</span></div>
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<span style="font-family: Times, "Times New Roman", serif;">Rest and activity avoidance were historically an integral part of Cancer Care. But evidence now indisputably confirms that every person with Cancer will, (and should), benefit from the prescription of a structured exercise medicine programme.</span></div>
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<span style="font-family: Times, Times New Roman, serif;">The days when we wrapped patients in cotton wool are gone, points out Dr David Speakman of Australia’s Peter MacCallum Cancer Centre. “Our attitudes to treating cancer, what it takes to give people their best chance at survival, have to change. All cancer patients will benefit from an exercise prescription.”</span></div>
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<span style="font-family: Times, Times New Roman, serif;">COSA Associate Professor Prue Corrie comments: “Really we are at the stage where the science is telling us that withholding exercise from cancer patients can be harmful. Exercise is the best medicine someone with cancer can take in addition to standard cancer treatments. That’s because we know now that people who exercise regularly experience fewer and less severe treatment side-effects; cancer-related fatigue, mental distress, quality of life. They also have a lower risk of their cancer coming back, or dying from the disease."</span></div>
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<span style="font-family: Times, Times New Roman, serif;">Writing in the Australian research analysis publication The Coversation, Professor Cormie lays out COSA’s new thinking on exercise medicine. “If the effects of exercise could be encapsulated in a pill, it would be prescribed to every cancer patient worldwide and viewed as a major breakthrough in cancer treatment. If we had a pill called exercise it would be demanded by cancer patients, prescribed by every cancer specialist, and subsidised by government.”</span></div>
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<span style="font-family: Times, Times New Roman, serif;">Cormie recommends that health professionals worldwide should view exercise as a standard part every Cancer treatment plan, enabling patients to be as physically active as their current ability and conditions allow. For significant health benefits, they should aim for at least 150 minutes of moderate intensity aerobic exercise weekly and two to three resistance exercise sessions (such as weightlifting).</span></div>
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<span style="font-family: Times, Times New Roman, serif;">I strongly recommend readers to watch Professor Cormie’s enlightening presentation on the Youtube excerpt or listen to her 20 minute podcast published by the MJA. They are featured below.</span></div>
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<b style="text-align: left;">Further Reading</b></div>
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<b>COSA Position Statement</b><br /><a href="https://www.cosa.org.au/media/332488/cosa-position-statement-v4-web-final.pdf"><span style="font-size: x-small;">Exercise in Cancer Care</span></a></div>
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<b>Professor Cormie, Youtube</b><br /><a href="https://www.youtube.com/watch?v=xIQh4fUZkJs&feature=youtu.be"><span style="font-size: x-small;">Exercise medicine for Cancer survivors</span></a></div>
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<b>The Conversation</b><br /><a href="https://theconversation.com/every-cancer-patient-should-be-prescribed-exercise-medicine-95440"><span style="font-size: x-small;">Prescribing exercise medicine</span></a></div>
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<b>Medical Journal of Australia</b><br /><span style="font-size: x-small; font-weight: 400;"><a href="https://www.podomatic.com/podcasts/themja/episodes/2018-05-05T17_50_43-07_00" style="font-weight: 400;">Podacast interview with Professor Cormie on exercise behaviour and Cancer.</a></span></div>
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<span style="font-size: x-small;"><i>Filed 29.05.2018 <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></i></span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-30913206269755132312018-06-07T12:52:00.000+01:002018-06-07T12:53:19.351+01:0037. Treating Cancer with oncolytic viruses<div dir="ltr" style="text-align: left;" trbidi="on">
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<i style="background-color: transparent; font-size: 15px; text-align: left;">Photo: <a href="https://www.cancer.gov/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">National Cancer Institute</a></i></div>
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We tend to think of viruses as disease harbingers. Oncology researchers have found however that some viruses can be modified in the laboratory to infect and kill Cancer tumour cells while not harming healthy cells.</div>
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A small but growing number of patients are benefiting from this new-targeted but presently exceedingly expensive viral treatment approach.</div>
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After a decade of research, the <a href="https://www.fda.gov/" rel="noopener" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;" target="_blank">US Food and Drug Administration, (FDA),</a> and the European Medicines Agency (EMA) approved T-VEC in 2015. This is an oncolytic virus modification based on the herpes virus and approval followed successful phase III multi-centre clinical trials on patients suffering from metastasic skin cancer. It was later given the green light by the NHS in UK for use on patients with inoperable malignant melanoma. Skin cancer that is now the fifth most common cancer in UK, with more than 14,500 diagnosed each year.</div>
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Oncolytic viruses, (OVs), used in virotherapy can not only kill cancer cells, but also trigger an immune response in the body against cancer. When a virus infects a tumour cell, the virus makes copies of itself until the cell bursts. The dying cancer cell releases toxic tumour antigens. These alert the body’s immune system and stimulate it to respond to the danger, not only from nearby cancer cells in the primary cancer site but of those that have migrated to other parts of the body in a secondary malignant metastatic growth.</div>
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These are still early days in oncolytic viral research and immunotherapy. But many more studies and clinical trials are underway across the world. They will provide insights into oncolytic virus use in combination therapies that not only kill cancer cells, but also enhance the body’s immune response to promote anti-tumour immunity.</div>
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<strong>Further Reading</strong></div>
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<strong>OncoImmunology</strong></div>
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<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760283/">First oncolytic virus approved for melanoma immunotherapy</a></div>
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<strong>Human Gene Therapy</strong></div>
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<a href="https://www.liebertpub.com/doi/10.1089/hum.2017.212">Fighting Cancer with Viruses: Oncolytic Virus Therapy in China</a></div>
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<i>Filed 02.04.2018 <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></i></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-60773524414091202982018-06-07T12:34:00.004+01:002018-06-07T12:36:47.655+01:0036. Drug trial for aggressive breast cancer and hormone therapy<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgMzVHra1Ag9BE8BSLdKbbzojgyNvfySJB2Kk_hFlyrbmf7fGMB0LUwQFeWy7bWdwtBG-rloS5MMkkSAZaF-QmkUnJD7NxxNt_6DpDSLFvjCjDvxVB4Zplr7e3C1YIT9rmQf4aa9k9YM2c/s1600/Pietras.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="480" data-original-width="640" height="480" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgMzVHra1Ag9BE8BSLdKbbzojgyNvfySJB2Kk_hFlyrbmf7fGMB0LUwQFeWy7bWdwtBG-rloS5MMkkSAZaF-QmkUnJD7NxxNt_6DpDSLFvjCjDvxVB4Zplr7e3C1YIT9rmQf4aa9k9YM2c/s640/Pietras.jpg" width="640" /></a></div>
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Approximately 10–15 per cent of breast cancer tumours do not respond to treatment with standard hormone therapy, which means that they are more aggressive and often recur.</div>
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An international research team led by Professor Kristian Pietras at Lund University, Sweden, has uncovered a way to treat these aggressive tumours through manipulation of the connective tissue cells of the breast cancer.</div>
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“Previously, it was believed that the various subgroups of breast cancer originated from different cell types in the mammary gland. Our research has shown that connective tissue cells can also modify tumour cells directly with regard to their sensitivity to hormones, which has significant implications in the development of more effective treatments”, states Professor Ulf Eriksson of Stockholm’s Karolinski Institute, who collaborated in the study.</div>
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The researchers tested a new biological drug they developed which blocked the PDGF-CC-mediated communication between the tumour cells and the connective tissue cells. This resulted in the transformation of the basal breast cancers into hormone-sensitive luminal breast cancers that were highly responsive to conventional hormone therapy.</div>
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“We have thus developed a new treatment strategy for aggressive and difficult-to-treat breast cancers that restores sensitivity to hormone therapy. These findings have major implications in the development of more effective treatments for patients with aggressive breast cancer”, concludes Kristian Pietras.</div>
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Following this study, the researchers are developing a new drug for trial which will transform aggressive breast cancer tumour so that they respond to standard hormone therapy.<br />
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<span style="font-size: x-small;"><i>Filed 26.03.2018. <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></i></span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-49951823379282417052018-06-07T11:52:00.001+01:002018-06-07T12:21:08.888+01:0035. Multi-targeted immunotherapy trial in Childhood Leukaemia<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="font-size: x-small;">Lymphoblasts from an ALL patient stained in blue. Photo courtesy of Nirali Shah</span></i></div>
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Following news of a phase 3 trial of AstraZeneca’s experimental drug (<em>In The News</em> 23.03.18), we are notified of a new phase 1 clinical trial being conducted at Bethesda Hospital, Maryland, for <a href="https://www.cancer.gov/types/leukemia/patient/adult-all-treatment-pdq" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;">acute lymphoblastic leukemia (ALL)</a> treatment. It will use a double-barrelled approach that targets two proteins found on the surface of the cancer cells.</div>
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In ALL the bone marrow makes abnormally high levels of immature white blood cells called lymphoblasts. Using <a href="https://www.cancer.gov/about-cancer/treatment/research/car-t-cells" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;">chimeric antigen receptor (CAR) T cells</a> to attack Cancer cells has shown promise as an emerging ALL treatment and will be the approach used in this new trial.</div>
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In this trial therapy, headed by Nirali Shah M.D., of the US National Cancer Institute, CAR T cells—white blood cells that defend the body against disease—are collected from patients and engineered in the laboratory to express receptors that target the two specific proteins on the surface of cancer cells. The collected CAR T cells are prodded to proliferate in the clinic and then infused back into patients. The clinicians expect that these cells will further proliferate in the body, hone in on the cancer cells bearing the surface protein target and kill them.</div>
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70 - 90% of ‘ALL’ patients who have relapsed or become resistant to chemotherapy can achieve remission of their disease after receiving CAR T-cell therapy that targets a protein found on the surface of lymphoblasts. But 30 - 50% of these patients suffer a further relapse.</div>
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Success in this strategy of targeting two proteins simultaneously will bring CAR T-cell therapy closer to durable remission in the most common of childhood Cancers.</div>
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Filed 16 April, 2018,<a href="http://caringcancertrust.com/"> Caring Cancer Trust</a></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-13741169982063333512018-06-07T11:22:00.001+01:002018-06-07T12:22:27.303+01:0034. Genomic Differences between Childhood and Adult Cancers<div dir="ltr" style="text-align: left;" trbidi="on">
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A recent pan-cancer study in USA published in Nature, 28 February, has found that several cancer types are genetically different in children and adults.</div>
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The paediatric study, led by Jinghui Zhang, Ph.D., at St. Jude Children's Research Hospital, Memphis, analysed samples from nearly 1,700 patients, aged 20 or younger, looking at all non-inherited, or somatic, genetic alterations. Adult patients in the TARGET study elsewhere in USA had common childhood cancers, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), neuroblastoma, Wilms tumour, and osteosarcoma.</div>
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The researchers identified 142 altered genes that drive the development of these cancers (driver mutations), of which only 45% are found in adult cancers.</div>
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The findings reinforce the growing belief that drugs developed and approved to treat cancers in adults may not always be effective or appropriate for children with the same cancer types, emphasising the need for paediatric cancer-specific development of precision therapies.</div>
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<b>Further Reading</b></div>
<a href="https://www.nature.com/articles/nature25795">Nature, International Journal of Science.</a><br />
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Filed 24 April, <a href="http://caringcancertrust.com/">Caring Cancer Trust.</a></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-13812629134701270292018-06-07T11:09:00.000+01:002018-06-07T12:23:17.920+01:0033. Childhood Leukaemia Targeted Therapy Trialsdrug trial success<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: "times" , "times new roman" , serif; font-size: x-small;"><i>Photo: Rosewell Park Cancer Center, Buffalo, NY.</i></span></div>
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<span style="font-family: "times" , "times new roman" , serif;">Stage 3 trials of an experimental targeted cancer drug produced by AstraZeneca that includes a bacterial toxin shows promise in treating the most common cancer in children, <u>B</u>-cell acute lymphoblastic leukaemia (ALL). However, therapeutic benefits in the trial appear to be limited, because trial patients are quickly developing therapeutic resistance to the drug and relapse.</span></div>
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<span style="font-family: "times" , "times new roman" , serif;">A US trial however has shown that resistance to the targeted toxin-based therapy can possibly be overcome by combining it with another leukaemia drug, (Moxe), thus increasing its efficacy in patients with relapsed and chemotherapy-resistant (refractory) ALL.</span></div>
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<span style="font-family: "times" , "times new roman" , serif;">Elsewhere <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2016-00973&r=1" style="color: #3783c1; outline: none; text-decoration-line: none; transition: color 0.4s;">Pilot phase 2 trials</a> involving 154 children’s hospitals across USA are underway to test combination treatment for ALL, its infant tolerability and long-term event-free infant survival. The trials use a cocktail of targeted chemotherapy drugs that work in three different ways to stop cancer cell growth; by killing the cells, by stopping them from dividing, or by stopping them from spreading.</span></div>
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<span style="font-family: "times" , "times new roman" , serif;">There is still a long way to go before the long-term efficacy of targeted drug combinations are proven, accepted and licensed by the FDA in USA and the NHS in UK for treating infant leukaemia. Research clinicians however are showing significant progress in harnessing the body’s own defence system by using modified T-cell based therapy to attack and kill cancer cells in both ALL and other cancers; a radically different approach to previous conventional chemotherapy treatments.</span></div>
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<span style="font-family: "times" , "times new roman" , serif;">Genetically modified so-called chimeric antigen receptor (CAR) T-cells are showing remarkable efficacy for the treatment of chemotherapy resistant relapsed B-cell ALL, and other cancers, although tumour cells still adapt to evade even this new type of treatment. It is hoped that selecting the right combination of therapies will limit the ability of cancer cells to escape such combinatorial approaches to treatment.</span></div>
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<span style="font-family: "times" , "times new roman" , serif;"><i>Filed March, 2018, <a href="http://caringcancertrust.com/">Caring Cancer Trust.</a></i></span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-58080051074657368252018-06-07T10:50:00.001+01:002018-06-07T12:24:45.887+01:0032. NHS RAPID pathway to prostate cancer diagnosis<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: "times" , "times new roman" , serif;">A new pilot high-speed path to treatment for prostate cancer that can significantly cut diagnosis time was presented at the European Association of Urology Conference in Copenhagen in March by Professor Hashim Ahmed, Chair of Urology at Imperial College London.</span></div>
<div style="background-color: white; color: #4a4a4a; margin-bottom: 25px; text-align: justify;">
<span style="font-family: "times" , "times new roman" , serif;">The procedure can cut waiting time for detection in the UK from an average 56 days to 17 days after referral from GP. As the difference between early and late detection of the disease is a matter of life and death, this new rapid procedure could save many lives if rolled out by the NHS across the country in the 2020s, following clinical trials.</span></div>
<div style="background-color: white; color: #4a4a4a; margin-bottom: 25px; text-align: justify;">
<span style="font-family: "times" , "times new roman" , serif;">The new world-leading (magnetic resonance imaging (MRI) procedure, is completed in one day rather than several. It was successfully piloted at London’s Imperial College Charing Cross Hospital and Epsom Hospital in 2017. Some 4 in 10 patients are cleared immediately after their MRI scan and the rest have a precision biopsy using fusion technology later that same day.</span></div>
<div style="background-color: white; color: #4a4a4a; margin-bottom: 25px; text-align: justify;">
<span style="font-family: "times" , "times new roman" , serif;">Professor Hashim Ahmed to led the treatment trial said: “<span style="color: #202a30; font-size: 18px;">The NHS has led the research that underpins this RAPID pathway to improve the diagnosis of prostate cancer. The NHS is now leading the way in ensuring all men get to benefit from this innovation. Fast access to high quality prostate MRI allows many men to avoid invasive biopsies as well as allowing precision biopsy in those men requiring it to find high risk tumours much earlier.”</span> access to high quality prostate MRI allows many men to avoid invasive biopsies as well as allowing precision biopsy in those men requiring it to find high risk tumour much earlier,”</span></div>
<div style="background-color: white; color: #4a4a4a; margin-bottom: 25px; text-align: justify;">
<span style="font-family: "times" , "times new roman" , serif;">Prostate cancer is now the second biggest killer for men after lung cancer. It kills over 10,000 men in UK, 28,000 in USA and 4,000 in Canada each year.</span><br />
<span style="font-family: "times" , "times new roman" , serif;"><br /></span>
<span style="font-family: "times" , "times new roman" , serif;"><i>Filed 22 March 2018 <a href="http://caringcancertrust.com/">Caring Cancer Trust</a></i></span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-17033283612100851842018-01-01T17:29:00.000+00:002018-06-07T12:27:14.509+01:0031. Breast Cancer Diagnosis Breakthrough<div dir="ltr" style="text-align: left;" trbidi="on">
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<span lang="EN-US"><span style="font-size: small;"> </span></span><span style="font-size: 16pt;"> </span><span style="font-size: 16pt;">Recent
research led by University College London has identified a cancer signature in
DNA changes apparent in blood tests. These signal a possibly fatal breast
cancer symptom up to one year earlier than current medical diagnosis techniques
which may still test negative in current breast screening.</span><br />
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<br />
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<span lang="EN-US" style="font-size: 16.0pt;"> “This
may enable individualised treatment, which could even begin in the absence of
radiological evidence in the breast,’ UCL’s Professor Martin Widschwendler, who
co-authored the study, has stated. <o:p></o:p></span></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 16.0pt;">
Such early detection and consequent early hormone treatment could mean a
difference between life and death. It would also eliminate the possibility of
over-diagnosis and subsequent debilitating treatment of slow growing but benign
tumours that are frequently detected in mammography screening. <o:p></o:p></span></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 16.0pt;">
Further study and trials are necessary before this early detection
process can be made available on the NHS or in USA. <o:p></o:p></span></div>
<div class="MsoNormal">
<span lang="EN-US" style="font-size: 16.0pt;"> Latest statistics show that 1 in 8 women in
UK and USA will be diagnosed with breast cancer at sometime in their lifetime. Breast
and lung cancers are, in fact, the foremost cause of female cancer death in
these countries. <o:p></o:p></span></div>
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<span lang="EN-US" style="font-size: 16.0pt;"> The
incidence of breast and lung cancer is in fact increasing, thanks to </span><span style="color: #333333; font-size: 16.0pt;">the growth and ageing of the population, together with
an increasing prevalence of risk factors associated with economic growth and
urbanisation, such as smoking, obesity, diet, and physical inactivity. </span><span lang="EN-US" style="font-size: 16.0pt;"><o:p></o:p></span></div>
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<span lang="EN-US"> </span><span lang="EN-US" style="font-size: 16.0pt;"> As with all
cancers, the risk of developing breast, (or other), cancer depends on a number
of factors that are possibly outside your immediate control. <o:p></o:p></span></div>
<div class="MsoNoSpacing">
<span lang="EN-US" style="font-size: 16.0pt;"> You
can however eliminate the breast cancer risk by cutting alcohol out altogether,
or at least down to the national guidelines, to ensure that you are not one of
the 12,000 new cases of cancer in UK each year caused by alcohol, which include
cancers of the mouth, throat, larynx, oesophagus, breast, live and bowel. <o:p></o:p></span></div>
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<span lang="EN-US" style="font-size: 16.0pt;">
Post-menopausal women who are overweight or obese are also at increased
breast cancer risk. Since both alcohol
and obesity significantly increase the risk factor for a large number of
cancers for both sexes at any age, you can do yourself a big favour if you
over-indulge on the booze and/or are overweight by changing your lifestyle. <o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 37pt; text-indent: -19pt;">
<!--[if !supportLists]--><span lang="EN-US" style="font-size: 16.0pt; mso-bidi-font-family: Cambria; mso-bidi-theme-font: minor-latin; mso-fareast-font-family: Cambria; mso-fareast-theme-font: minor-latin;">1.<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;">
</span></span><!--[endif]--><span lang="EN-US" style="font-size: 16.0pt;">Cut
down on the booze! <o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 18pt;">
<span lang="EN-US" style="font-size: 16.0pt;">2. Change your diet to lose weight! <o:p></o:p></span></div>
<div class="MsoNoSpacing">
<span lang="EN-US" style="font-size: 16.0pt;">
3. Get out and stretch those
legs! <o:p></o:p></span></div>
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<!--StartFragment--><!--EndFragment--><br />
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<span lang="EN-US"><span style="font-size: small;"><b>Ian MacWatt</b></span></span></div>
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<b style="text-align: left;"><span style="background: white; color: #333333;"><span style="font-size: small;"><i>Further
Reading</i></span></span></b></div>
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<br /></div>
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<b style="mso-bidi-font-weight: normal;"><span style="background: white;"><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0499-9"><span style="font-size: small;">GenomeMedicine</span></a></span></b></div>
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<span style="font-size: small;"><span lang="EN" style="color: #1b3051;"><span style="mso-spacerun: yes;"> </span>Methylation patterns in serum DNA for
early identification of disseminated breast cancer. Report on the UCL Study.</span><span style="background: white; color: blue;"><o:p></o:p></span></span></div>
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<a href="https://www.sciencedaily.com/releases/2015/02/150204102633.htm"><span style="font-size: small;"><b><span lang="EN" style="color: #1b3051;">Science Daily</span></b><span lang="EN" style="color: blue;"> </span></span></a></div>
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<span style="font-size: small;"><span lang="EN-US" style="background: white;"><span style="mso-spacerun: yes;"> </span></span><span style="background: white;">Lung cancer and breast cancer; the
leading cause of female cancer death in developed countries.<span style="mso-spacerun: yes;">
</span><o:p></o:p></span></span></div>
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<b style="mso-bidi-font-weight: normal;"><span style="background: white;"><a href="https://www.wcrf-uk.org/uk/preventing-cancer"><span style="font-size: small;">World Cancer Research Fund</span></a></span></b></div>
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<span style="background: white;"><span style="font-size: small;"><span style="mso-spacerun: yes;"> </span>Cancer Prevention<o:p></o:p></span></span></div>
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<b><span lang="EN" style="color: #1b3051;"><a href="https://stopcanceruk.blogspot.co.uk/2017/03/cancer-prevention-and-obesity.html"><span style="font-size: small;">Stop Cancer</span></a></span></b></div>
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<span lang="EN"><span style="font-size: small;"><span style="mso-spacerun: yes;"> </span>Obesity and Cancer<o:p></o:p></span></span></div>
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<b><a href="https://www.nature.com/articles/nature25154">Nature</a></b><br />
Alcohol damages DNA and increases cancer risk</div>
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<i>Filed March 2018<a href="http://caringcancertrust.com/"> Caring Cancer Trust</a></i></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-52459625294909131382017-12-11T13:17:00.000+00:002017-12-11T13:21:22.747+00:0030. Breast Cancer Prevention - New Study<div dir="ltr" style="text-align: left;" trbidi="on">
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<span lang="EN-US" style="font-size: 16.0pt;"><br /></span></div>
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<span lang="EN-US" style="font-size: 16.0pt;"><br /></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDoqNKKpBn-JhVEsCBKEfh5JpBExozEz1lgDzaai-Bw4PP64toInaH19F1S6VeZakyn6kiwugrEFhEDCogruG8KkdwhrAVDCfrV1XZq00j-t-T3rR0ZkyC-IIHHk6lnYNYOOHF-NNnYDw/s1600/knowyourlemons.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="855" data-original-width="1201" height="452" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDoqNKKpBn-JhVEsCBKEfh5JpBExozEz1lgDzaai-Bw4PP64toInaH19F1S6VeZakyn6kiwugrEFhEDCogruG8KkdwhrAVDCfrV1XZq00j-t-T3rR0ZkyC-IIHHk6lnYNYOOHF-NNnYDw/s640/knowyourlemons.png" width="640" /></a></div>
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<br /></div>
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<span lang="EN-US" style="font-size: 16.0pt;"><br /></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"> Overweight women can reduce the risk of
contracting breast cancer by losing just 7 pounds, (3.2kilo) according to new
study presented at the San Antonio Breast Cancer Symposium this month. This is a
modest weight loss with a significant effect. However if they lose 28 pounds,
((12.7 kilos), that risk is reduced by no less than 33 percent. <o:p></o:p></span></div>
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<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;">
</span>The study tracking 61,335 women aged between 50 and 79 over 14 years was
undertaken by the City of Hope Medical Centre, California and Harvard
University, Boston.<o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;"> </span><span style="mso-spacerun: yes;"> </span>It has been known for some time that obesity
increases the risk of breast cancer, as it does for cancer of the uterus. as is
cancer of the uterus. Obesity in either sex can also lead to other cancers,
including esophageal, stomach, liver, gallbladder and pancreatic cancers. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;"> </span>Lead
author of the study findings, Professor Rowan Chlebowski commented: ‘we found
that relatively modest weight loss was linked to a statistically significant
lower breast cancer incidence. That’s pretty remarkable.’<o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;"> </span>The statistics also showed that women who gained excess weight during
the study had 54 per cent greater risk of developing difficult to treat Triple-Negative
Breast Cancer, which afflicts one in six women of diagnosed with this disease. <span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;">
</span>Statistics show that one in eight women in the UK are likely to develop
breast cancer in the course of their lifetime, which equates to some 55,000
cases diagnosed annually. Furthermore, the numbers are rising as the population
ages and become overweight or obese. <o:p></o:p></span></div>
<div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 16.0pt;"><span style="mso-spacerun: yes;"> </span>Professor Ian Hampson of the University of Manchester Division of Cancer
Sciences states: ‘ Together with smoking, obesity is now another well-established
cause of cancer. Thus it is very clear that simple changes in lifestyle can very
significantly reduce the risk of cancer.<span style="mso-spacerun: yes;">
</span>The most remarkable thing about this new study is that such most changes
in body mass can have such a profound effect.’<o:p></o:p></span></div>
<div align="right" class="MsoNormal" style="text-align: right;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 16.0pt;">Ian MacWatt<o:p></o:p></span></b></div>
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Reading <o:p></o:p></span></b></div>
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<span style="font-size: 16pt;">Overview</span></div>
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<span style="font-size: 16pt;"><b><a href="https://www.pinterest.co.uk/pin/574490496199759727/">Pinterest</a></b></span></div>
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<span style="font-size: 16pt;"><a href="https://stopcanceruk.blogspot.co.uk/2017/03/cancer-prevention-and-obesity.html"><b>Stop Cancer</b></a></span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-65333953098599118832017-11-07T18:48:00.001+00:002017-11-07T19:00:04.423+00:00 29. Diet and Colorectal Cancer Prevention<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<br /></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 16.0pt;"><br /></span></b></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQSj_KLy-0pGoGg8TxM1ldYxCW_pBTgceseNPGy6LyDW-7khpwQWbfkYFui94Zoi08LgSQjQJ3EkfFaCqKviP_0eL7EO9weBs9jnWtljVI18vLSbsn3ZvS3nset2J9meWGveY6qaA4qfc/s1600/Diet-and-lifestyle-770x360.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="360" data-original-width="770" height="297" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQSj_KLy-0pGoGg8TxM1ldYxCW_pBTgceseNPGy6LyDW-7khpwQWbfkYFui94Zoi08LgSQjQJ3EkfFaCqKviP_0eL7EO9weBs9jnWtljVI18vLSbsn3ZvS3nset2J9meWGveY6qaA4qfc/s640/Diet-and-lifestyle-770x360.jpg" width="640" /></a></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 16.0pt;"><br /></span></b></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 16.0pt;"><br /></span></b></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 16.0pt;">Diet and Colorectal Cancer Prevention<o:p></o:p></span></b></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<br /></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>Research shows that diet and exercise
provide powerful protection against colorectal cancer according to a recent
report by the American Institute of Cancer Research and the Scotland-based
Worldwide Cancer Research.<o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>“This report demonstrates that there is a
lot people can do to dramatically lower their risk" says Edward L
Giovannucci, Professor of nutrition and epidemiology at the Harvard TH Chan
School of Public Health.<o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>The report shows a clear relationship
between eating whole grains daily and a reduction in colorectal cancer risk.
The more you eat, the lower the risk. Eating three servings a day reduces the risk
by a remarkable 17 percent; a useful addition to a 'Stop Cancer' diet!<o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>Evidence confirms the known fact that
overweight and obesity adds noticeably to the risk not only to colorectal
cancer but also to a plethora of other cancers, as does the lack of regular
exercise.<o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>The report points to emerging evidence
that a diet with fish, and fruit and non-starchy vegetables high in vitamin C
help to provide cancer prevention. However it strengthens the link between
colorectal cancer and over-consumption of red or processed meats.“<o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>As research continues to emerge for these
factors, it all points to the power of a plant-based diet, says Alice Bender,
AICR Director of Nutrition Programs. <o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>“Replacing some of your refined grains
with whole grains and eating mostly plant foods, such as fruits, vegetables and
beans, will give you a diet packed with cancer-protective compounds and help
you manage your weight, which is so important to lower risk.<span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;">
<span lang="EN-US" style="font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>“When it comes to cancer there are no
guarantees, but it’s clear now there are choices you can make and steps you can
take to lower your risk of colorectal and other cancers,” she points out.<o:p></o:p></span><br />
<span lang="EN-US" style="font-size: 14.0pt;"><b><br /></b></span>
<div style="text-align: right;">
<span lang="EN-US" style="font-size: 14.0pt;"><b>Ian MacWatt</b></span></div>
</div>
<div style="background: white; margin-bottom: 18.75pt; margin-left: 14.2pt; margin-right: 0cm; margin-top: 0cm;">
<br /></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt;">
<strong><span lang="EN-US" style="color: #4a4a4a; font-family: "helvetica"; font-size: 14.0pt;">Further Reading</span></strong><span lang="EN-US"><o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt;">
<strong><span lang="EN-US" style="color: #4a4a4a; font-family: "helvetica"; font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>AICR eNews</span></strong><span lang="EN-US"> <a href="http://www.aicr.org/enews/2017/september/enews-new-colorectal-cancer-report-whole-grains-lower-risk-processed-meat-increases.html"><span style="color: #3783c1; font-family: "helvetica"; font-size: 14.0pt; text-decoration: none;">New colorectal cancer report</span></a><o:p></o:p></span></div>
<div class="MsoNoSpacing" style="margin-left: 14.2pt;">
<strong><span lang="EN-US" style="color: #4a4a4a; font-family: "helvetica"; font-size: 14.0pt;"><span style="mso-spacerun: yes;"> </span>AICR</span></strong><span lang="EN-US"><span style="mso-spacerun: yes;"> </span><a href="http://www.aicr.org/foods-that-fight-cancer/"><span style="color: #3783c1; font-family: "helvetica"; font-size: 14.0pt; text-decoration: none;">Foods That Fight Cancer</span></a><o:p></o:p></span></div>
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</style>Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-90689712742149388292017-11-05T15:38:00.000+00:002017-11-05T16:10:15.068+00:0028. Stomach Drugs, Cancer and Lifestyle<div class="MsoNormal" style="background: white; line-height: 18.0pt; margin-bottom: 7.5pt; margin-left: -35.45pt; margin-right: 0cm; margin-top: 0cm;">
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<b style="font-size: 12pt;"><span style="color: #333333; font-size: 18.0pt;">Stomach Drugs, Cancer and Lifestyle</span></b></div>
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<span style="font-size: 14pt;"> An association between proton pump
inhibitor drugs, (PPIs) and stomach cancer has finally been positively
identified. A study by the University of Hong Kong and University College
London published in <b><i>Gut</i></b>, a leading international journal in gastroenterology
and herpetology, has shown that long term use of PPIs presents a 2.4 times
higher risk of developing stomach cancer. </span><span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";"><o:p></o:p></span></div>
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A link between PPIs and a higher stomach cancer risk has previously been
identified by academics – but never in a study that first eliminates </span><i><span style="background: white; color: #333333; font-size: 14.0pt;">Helicobacter
pylori</span></i><span style="background: white; color: #333333; font-size: 14.0pt;"> (HP)</span><span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">, </span><span style="color: #333333; font-size: 14.0pt;">a bacterium suspected
of fuelling the illness’s development.</span><span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";"><o:p></o:p></span></div>
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<span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";"> The PPI study </span><span style="color: #333333; font-size: 14.0pt;">found that after HP was removed, the risk of
developing the disease still rose in line with the dose and duration of PPI
treatment. However patients on H2
blockers, another class of drugs that are prescribed to reduce stomach acid
production, had no increase in cancer prevalence compared to those on PPIs. <o:p></o:p></span></div>
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<span style="color: #333333; font-size: 14.0pt;">
More than 50m prescriptions for PPIs are handed out every year in UK for
stomach ulcers and their causes. PPIs are also prescribed for acid reflux
causing heartburn and inflammation of the gullet, (which can itself lead to oesophageal
cancer).<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt; text-align: justify;">
<span style="color: #333333; font-size: 14.0pt;">
As always, prevention is better than cure. Acid reflux and consequent
heartburn and inflammation of the gullet, can be caused by obesity, smoking or
alcohol excess. Any of these can lead to a number of life-threatening cancers. Combined
together, obesity, tobacco and alcohol excess are a lethal cocktail that
will certainly ensure a shortened life, if not from one of a number of consequent
cancers such as cancer of </span><span style="background: white; color: #333333; font-family: "arial"; font-size: 14.0pt;">the colon, rectum, liver, gallbladder, pancreas,
kidney, gullet or postmenopausal breast.</span><span style="font-family: "times"; font-size: 14.0pt;"><o:p></o:p></span></div>
<div align="right" class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt; text-align: right;">
<br /></div>
<div align="right" class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt; text-align: right;">
<b><span style="color: #333333; font-size: 14.0pt;">Ian MacWatt<o:p></o:p></span></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt; text-align: justify;">
<br /></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;">Further Reading<o:p></o:p></span></b></div>
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<b><br /></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><a href="http://gut.bmj.com/content/early/2017/09/18/gutjnl-2017-314605">Gut MBJ</a> </span></b><span style="font-size: 14pt;">PPIs and gastric cancer risk study</span></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><br /></span></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><a href="https://patient.info/health/proton-pump-inhibitors">Patient Platform</a> </span></b><span style="font-size: 14pt;">Proton Pump Inhibitors</span></div>
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<b><span lang="EN-US" style="font-size: 14.0pt;"><br /></span></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><a href="https://patient.info/health/proton-pump-inhibitors">Healthline</a> </span></b><span style="font-size: 14pt;">H2 Blockers</span></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><br /></span></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<b><span lang="EN-US" style="font-size: 14.0pt;"><a href="https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet">National Cancer Institute</a> </span></b><span style="font-size: 14pt;">Obesity and Cancer</span></div>
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<b><span lang="EN-US" style="font-size: 14.0pt;"><br /></span></b></div>
<div class="MsoNormal" style="margin-left: 7.1pt; margin-right: 18.1pt;">
<span lang="EN-US" style="font-size: 14pt;"><a href="http://www.nejm.org/doi/10.1056/NEJMsr1606602" style="font-weight: bold;">New England Journal ofMedicine</a><b> </b>Body Fatness and Cancer<b><o:p></o:p></b></span></div>
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<br /></div>
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<b><span lang="EN-US" style="font-size: 14.0pt;"><a href="https://www.nhs.uk/conditions/indigestion/">NHS Choice</a> </span></b><span style="font-size: 14pt;">Indigestion</span></div>
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<br /></div>
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</style>Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0United Kingdom55.378051 -3.4359729999999912.203021 -86.05316049999999 90 79.18121450000001tag:blogger.com,1999:blog-2067211831338877533.post-57997080491019911612017-03-27T16:20:00.001+01:002017-11-07T23:49:51.312+00:0027. Cancer Prevention and Obesity<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="color: #333333; font-family: "helvetica"; font-size: 16.0pt;"> </span><span style="color: #333333; font-family: "helvetica";"><span style="font-size: x-small;"> </span></span><br />
<div class="separator" style="clear: both; text-align: center;">
<span style="color: #333333; font-family: "helvetica";"><span style="font-size: x-small;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXrzlldaTqAn7l29_T4NhZvMg2pE0RsgYeIdCvh-blVTD4xnQ5nkMabIiC3CDy-Ctv9qSZk4ajQ48DInZ4fwpfjgABNOFvyeLuzp5XphyhUzu1Y6YtFFBXhvAg4wcbKZBwhpxyeuFXWxU/s1600/dutch+heart+%25281%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="300" data-original-width="300" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXrzlldaTqAn7l29_T4NhZvMg2pE0RsgYeIdCvh-blVTD4xnQ5nkMabIiC3CDy-Ctv9qSZk4ajQ48DInZ4fwpfjgABNOFvyeLuzp5XphyhUzu1Y6YtFFBXhvAg4wcbKZBwhpxyeuFXWxU/s400/dutch+heart+%25281%2529.jpg" width="400" /></a></span></span></div>
</div>
<span style="font-family: "cambria"; font-size: 14pt; text-align: justify;"> With
the passing of each month the importance of healthy diet, lifestyle and exercise in Cancer Prevention becomes more evident. </span><span style="font-family: "cambria"; font-size: 14pt; text-align: justify;">Recent
studies in USA have shown that unhealthy lifestyle factors are responsible for
over 70% of a number of different Cancers diagnosed; cancers that could well
have been prevented by an improved Stop Cancer diet, a healthy lifestyle and
adequate exercise. </span><span style="color: #333333; font-family: "helvetica";"></span><br />
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<!--StartFragment-->
<br />
<div class="MsoNormal" style="margin-left: 21.3pt;">
<span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial;"> We all know
the danger of lung cancer from smoking, but most are ignorant of the risk of
throat cancer from alcohol excess, or obesity </span><span lang="EN-US" style="font-size: 14.0pt;">.</span><span style="font-size: 14.0pt; mso-ansi-language: EN-GB;"><o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 21.3pt;">
<span style="font-size: 14.0pt; mso-ansi-language: EN-GB;"> Recent World Health Organisation
statistics for the EU show that 40-50% of men and 25-35% of women are
overweight thanks to poor diet and sedentary habits, and some 50% of these are
obese. In USA the figures are worse: 68% of adults are overweight and 33.8%
obese. In UK, one in five children aged 10 are now considered obese
Obesity is now a major causation factor or risk elevation for a
considerable number of cancers. Indeed obesity looks set to overtake smoking as
the major cause of cancer.
<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 21.3pt;">
<span style="font-size: 14.0pt; mso-ansi-language: EN-GB;"> The list of cancers that can be caused
from obesity is daunting: cervical; colorectal; endometrial, (lining of the
uterus); oesophagus, (gullet); hepatocellular, (subtype of liver cancer);
gallbladder; kidney; malignant </span><span lang="EN-US" style="font-size: 14.0pt;">melanoma;
post-menopausal breast cancer; non-Hodgkinson’s Lymphom, thyroid cancer. </span><span style="font-size: 14pt;">The present parlous state of the NHS in
the UK, together with the US President’s desire to slash federal funding for
Medicare, Medicaid and the US Institute of National Health, make the reduction
of obesity ever more crucial in primary cancer prevention as well as in
cancerous growth and metastasis, (development of secondary malignant tumour
growths at a distance from a primary cancer site). </span></div>
<div class="MsoNormal" style="margin-left: 21.3pt;">
<span style="font-size: 14pt;"> In addition
to essential weight loss and a healthy lifestyle in cancer prevention, there
are a number of plant-based foods that have nutrients, which appear in studies
to have cancer-preventive properties as well as inhibiting cancer growth and
metastasis. Unlike sugar, which feeds sucrose-loving cancer tumours, they help
to starve and eliminate cancer cells and the growth of blood cells that tumours
feed on. Their </span><span style="font-size: 18.6667px;">phytochemical</span><span style="font-size: 14pt;"> interferes with the cellular communication that
triggers inflammation and stimulates the emergence and progression of cancer
tumours in the body. In effect they become biological response
modifiers, changing the way the body works. <o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 21.3pt;">
<span style="font-size: 14.0pt; mso-ansi-language: EN-GB; mso-bidi-font-family: Arial;"> </span><span style="font-size: 14.0pt; mso-ansi-language: EN-GB;">While all the nutrients shown
below can be taken as (sometimes expensive) supplements, they are present in
the sort of fresh organic vegetables, fruits, fish and dairy products that can
be found in healthy eating such as the Mediterranean Diet.<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 21.3pt;">
<br /></div>
<div class="MsoNormal" style="margin-left: 35.45pt; text-indent: -14.15pt;">
<b style="font-size: 12pt; text-align: left; text-indent: -14.15pt;"><span style="font-size: 14.0pt; mso-ansi-language: EN-GB;"><span style="color: purple;"> <a href="https://pubchem.ncbi.nlm.nih.gov/compound/Ursolic_acid#section=Top">Ursolic Acid.</a></span></span></b><span style="font-size: 14pt; text-align: left; text-indent: -14.15pt;"> Present in apples, basil,
bilberries, cranberries, elderflower, peppermint, rosemary, lavender, oregano,
thyme, hawthorn, prunes.</span></div>
<div style="text-align: left;">
<span style="font-size: 12pt; text-indent: -14.15pt;"> </span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/" style="background-color: white; font-size: 14pt; text-align: left; text-indent: -14.15pt;"><b style="font-size: 14pt; text-indent: -14.15pt;"><span style="color: #333333;">Vitamin D.</span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> </span></a><b style="background-color: white; color: #333333; font-size: 14pt; text-align: left; text-indent: -14.15pt;"> </b><span style="background-color: white; color: #333333; font-size: 14pt; text-align: left; text-indent: -14.15pt;">Present
in wild caught, (as opposed to farmed) fatty fish </span><span style="font-size: 12pt; text-indent: -14.15pt;"> like salmon, free
range eggs, whole milk, Sunlight. Cooking reduces vitamin D by 30%.</span></div>
<span style="font-size: 12pt; text-indent: -14.15pt;"></span><br />
<div style="text-align: left;">
<span style="font-size: 12pt; text-indent: -14.15pt;"><span style="font-size: 12pt; text-indent: -14.15pt;"> </span><a href="http://www.webmd.com/diet/supplement-guide-turmeric#1" style="background-color: white; font-size: 14pt; text-align: left; text-indent: -14.15pt;"><b style="font-size: 14pt; text-indent: -14.15pt;"><span style="color: #333333;">Curcumin.</span></b><span style="color: purple; font-size: 14pt; text-indent: -14.15pt;"> </span><span style="color: purple;"> </span></a><span style="background-color: white; color: #333333; font-size: 14pt; text-align: left; text-indent: -14.15pt;"> Present in turmeric
root.</span></span></div>
<span style="font-size: 12pt; text-indent: -14.15pt;">
<div style="text-align: left;">
<b style="font-size: 12pt; text-indent: -14.15pt;"><span style="color: #333333; font-size: 14.0pt;"><span style="color: purple;"> <a href="http://www.webmd.com/vitamins-supplements/ingredientmono-1070-sulforaphane.aspx?activeingredientid=1070&activeingredientname=sulforaphane">Sulforaphane</a></span>.</span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> <b> </b>Present in many cruciferous
vegetables such as </span><span style="font-size: 12pt; text-align: justify; text-indent: -14.15pt;"> cauliflower, brussels sprouts, cabbage, kale, kohlrabi,
turnip, radish, watercress.</span></div>
<div style="text-align: left;">
<b style="font-size: 12pt; text-indent: -14.15pt;"><span style="color: #333333; font-size: 14.0pt;"><span style="color: purple;"> <a href="http://umm.edu/health/medical/altmed/supplement/quercetin">Quercentin. </a></span></span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> Present in
onions, capers, blackberries, dark cherries, cocoa, kale, apples.</span></div>
<div style="text-align: left;">
<b style="font-size: 12pt; text-indent: -14.15pt;"><span style="color: #333333; font-size: 14.0pt;"><span style="color: purple;"> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/">Apigenin</a></span>. </span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> Present in
fresh grapefruit, onions, oranges, parsley, chamomile tea.</span></div>
<div style="text-align: left;">
<b style="font-size: 12pt; text-indent: -14.15pt;"><span style="color: #333333; font-size: 14.0pt;"><span style="color: purple;"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/18991571">Luteolin</a></span>.</span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> Present in green
peppers, celery, chamomile tea.</span></div>
<div style="text-align: left;">
<b style="font-size: 12pt; text-indent: -14.15pt;"><span style="color: #333333; font-size: 14.0pt;"><span style="color: purple;"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/17022020">Anthraquinones</a></span>. </span></b><span style="color: #333333; font-size: 14pt; text-indent: -14.15pt;"> Present in
rhubarb,</span></div>
</span><br />
<div style="text-align: left;">
<b style="color: #333333; font-size: 12pt; text-align: right; text-indent: -14.15pt;"><span style="font-size: 16pt;"> Ian MacWatt </span><span style="font-size: small;"> </span></b></div>
<div style="text-align: left;">
<br /></div>
<b style="font-size: 12pt; text-align: left; text-indent: -14.15pt;"><span lang="EN-US" style="color: #333333; font-size: 16.0pt;"></span></b><br />
<div class="MsoNormal" style="margin-left: 35.45pt; text-indent: -14.15pt;">
<b style="font-size: 12pt; text-align: left; text-indent: -14.15pt;"><span lang="EN-US" style="color: #333333; font-size: 16.0pt;"><b style="font-size: 12pt; text-align: left; text-indent: -14.15pt;"><span lang="EN-US" style="color: #333333; font-size: 16.0pt;"><br /></span></b></span></b></div>
<b style="font-size: 12pt; text-align: left; text-indent: -14.15pt;"><span lang="EN-US" style="color: #333333; font-size: 16.0pt;">
Further Reading</span></b><br />
<div class="MsoNormal" style="background: white; margin-left: 21.3pt;">
<br /></div>
<div class="MsoNormal" style="background: white; margin-left: 21.3pt;">
<span style="color: #333333;"><span style="font-size: small;"><span style="color: purple;"> <a href="https://www.omicsonline.org/open-access/the-association-between-obesity-and-cancer-2161-1017-1000196.pdf">The Association between obesity and cancer</a></span><o:p></o:p></span></span></div>
<div class="MsoNormal" style="background: white; margin-left: 21.3pt;">
<span style="color: #333333;"><span style="color: purple;"><span style="font-size: small;"> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789124/">Frugal Chemoprevention</a></span></span><span style="font-size: 14pt;"><o:p></o:p></span></span></div>
<div class="MsoNormal" style="background: white; margin-left: 21.3pt;">
<span style="color: #333333; font-family: "helvetica"; font-size: 10.0pt;">
</span><span style="color: #333333; font-family: "arial"; font-size: 11.0pt;"><o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 14.2pt;">
<br /></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-63958670461338401392016-06-22T08:33:00.001+01:002017-11-07T19:06:20.240+00:0026. Turmeric and Cancer Prevention<div class="MsoNoSpacing">
<span style="mso-ansi-language: EN-GB;"><br /></span></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
<span style="mso-ansi-language: EN-GB;"><br /></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfapwj4e8Rx2jlym8iTQSLxAM-E2BxR1kVvx5CdgYWQiMZ4MgChvxFhdybPQnUbX30INfm7QqPVRXJ8rKDbHfK8IAp4C8RtZvRkowBLQr9OhVayyEITfFIGfJUcdRQ2DQfhhjkECCQAyU/s1600/Curmin-image.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="281" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhfapwj4e8Rx2jlym8iTQSLxAM-E2BxR1kVvx5CdgYWQiMZ4MgChvxFhdybPQnUbX30INfm7QqPVRXJ8rKDbHfK8IAp4C8RtZvRkowBLQr9OhVayyEITfFIGfJUcdRQ2DQfhhjkECCQAyU/s400/Curmin-image.jpg" width="400" /></a></div>
<div class="MsoNoSpacing">
<span style="mso-ansi-language: EN-GB;"><br /></span></div>
<div class="MsoNoSpacing">
<span style="mso-ansi-language: EN-GB;"><br /></span></div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"> Turmeric root is
one of the most important 'Stop Cancer' nutrients thanks to Curcumin, the root’s
distinctive yellow pigment. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><span style="mso-spacerun: yes;"> </span><span style="mso-spacerun: yes;"> </span>Clinical
trials have shown it to combat breast, prostate, liver, colon, lung and
pancreas cancer among others. It <span style="mso-bidi-font-weight: bold;">actually
stops cancer cells from </span>multiplying by division and also triggers
programmed cell death, the body’s natural and necessary way of ridding itself
from damaged cells.<span style="mso-spacerun: yes;"> </span><span style="mso-bidi-font-weight: bold;">Curcumin has the ability to kill cancer cells
while leaving healthy cells unharmed.</span> It is still not widely prescribed
in cancer prevention or therapy as there is little financial incentive to do
so. <span style="mso-spacerun: yes;"> </span>Drug companies cannot patent natural
substances, and without a patent there is no profit.<o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><span style="mso-spacerun: yes;"> </span>You will receive many of the cancer
prevention benefits of Curcumin however, by using turmeric root in your
cooking. It has a light flavour and can be grated or chopped and added to
recipes.<span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><span style="mso-spacerun: yes;"> </span>The possibilities are endless with this
diverse spice.<span style="mso-spacerun: yes;"> </span>Add to curries or to
vegetables like rice or cauliflower, for both colour and flavour. Combine with
a little black pepper and/or olive oil or coconut oil, to significantly
increase the body’s absorption of Curcumin.<span style="mso-spacerun: yes;">
</span><o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><span style="mso-spacerun: yes;"> </span>To make a healing tea, finely slice or grate
fresh turmeric root. Add along with some grated or sliced ginger root to a
teapot and steep in hot water. Sweeten your tea if desired with local honey or
green leaf stevia. The longer you steep, the more intense the colour and flavour
of your tea.<span style="mso-spacerun: yes;"> </span>I make a batch each week
and refrigerate it, to drink first thing each morning with a little added lemon
juice. <o:p></o:p></span></div>
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><br /></span></div>
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><b>Further Reading</b></span></div>
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><b><a href="https://jeccr.biomedcentral.com/articles/10.1186/s13046-017-0566-5"><br /></a></b></span></div>
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;"><b><a href="https://jeccr.biomedcentral.com/articles/10.1186/s13046-017-0566-5">Jnl of Experimental & Clinical Cancer Research</a></b></span></div>
<div style="text-align: justify;">
<span style="mso-ansi-language: EN-GB;">Curcumin and Breast Cancer</span></div>
</div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-5101131291021741662016-05-16T15:03:00.002+01:002017-11-07T19:15:59.202+00:0025. The Stop Cancer effects of Coconut Oil <div class="MsoNormal" style="background: white; line-height: 15.0pt; text-indent: 1.0cm; vertical-align: baseline;">
<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
<div class="MsoNormal" style="background: white; line-height: 15.0pt; text-indent: 1.0cm; vertical-align: baseline;">
<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
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<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
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<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
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<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiz0jmbI0b5DddfeWpYjMzxCYQvSWiwuRjuSYlo8aAfKS2pCREThMLCqgqMYicz9bp9uAZWclL2bdLxTELrZYM9w_apH__HJEnWvkg2xOkcdSQmQvUsY0CyqhKgQs0xVgObgSNACwH2ilk/s1600/Coconut-oil+Bigstock.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="430" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiz0jmbI0b5DddfeWpYjMzxCYQvSWiwuRjuSYlo8aAfKS2pCREThMLCqgqMYicz9bp9uAZWclL2bdLxTELrZYM9w_apH__HJEnWvkg2xOkcdSQmQvUsY0CyqhKgQs0xVgObgSNACwH2ilk/s640/Coconut-oil+Bigstock.jpg" width="640" /></a></div>
<div class="MsoNormal" style="background: white; line-height: 15pt; text-align: justify; text-indent: 1cm; vertical-align: baseline;">
<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"> <i> Photo credit: Bigstock</i></span></div>
<div class="MsoNormal" style="background: white; line-height: 15.0pt; text-indent: 1.0cm; vertical-align: baseline;">
<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
<div class="MsoNormal" style="background: white; line-height: 15.0pt; text-indent: 1.0cm; vertical-align: baseline;">
<span style="color: #444444; font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
<div class="MsoNormal" style="background: white; line-height: 15.0pt; text-indent: 1.0cm; vertical-align: baseline;">
<div style="text-align: justify;">
<span style="color: #444444; font-family: "georgia"; font-size: 14pt; line-height: 15pt; text-indent: 1cm;">Colon
cancer is one of the most common cancers, affecting both men and women.</span><span style="color: #444444; font-family: "georgia"; font-size: 14pt; line-height: 15pt; text-indent: 1cm;"> </span><span style="color: #444444; font-family: "georgia"; font-size: 14pt; line-height: 15pt; text-indent: 1cm;">There have been a good number of natural
remedies and foods that have been linked to prevention of this cancer, but
there have not been many studies, which show that these remedies kill cancer
cells.</span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span style="font-family: "georgia"; font-size: 14.0pt;">However a recent study published
in the Journal <i>Cancer Research</i> has found an active anti-cancer component in
coconut oil. Lauric acid, a major ingredient of this oil, has been shown in a
University of Adelaide study to kill over 90% of the colon cancer cells after
just two days of treatment. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span style="font-family: "georgia"; font-size: 14.0pt;">This study was conducted in vitro,
but the researchers believe that lauric acid could also induce cancer cell
death in clinical studies as well.<span style="mso-spacerun: yes;"> </span><span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span style="font-family: "georgia"; font-size: 14.0pt;">Why is it that many <i>in vitro</i>
studies never get past this stage and move onto clinical trials? This is
because clinical trials are very expensive, making it difficult for those who
are not involved in mainstream pharmaceutical research, to find funding.<o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span style="font-family: "georgia"; font-size: 14.0pt;">Pharmaceutical companies have
little interest in funding these types of studies, as they cannot patent the
oil, so there is no money in it for them. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;">Clinical studies by the American
Society for Nutrition have shown that the fats in coconut oil can help to
prevent and treat diabetes, herpes, hepatitis, gallbladder disease, cancer, and
Crohn’s disease. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;">Coconut oil has also be shown to
decrease the toxic and often devastating side effects of chemotherapy. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<div style="text-align: justify;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;"><br /></span></div>
</div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;"><b><i>Further Reading</i></b></span></div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;"><a href="http://naturalon.com/this-one-oil-knocks-out-cancer-cells-like-crazy/2/"><b>Naturelon</b></a> Coconut Oil and Colon Cancer</span></div>
<div class="MsoNoSpacing" style="text-indent: 1.0cm;">
<span lang="EN-US" style="font-family: "georgia"; font-size: 14.0pt;"><a href="http://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-139"><b>Biomed Central</b></a> Cocont Oil and Breast Cancer</span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-20510868455062026682016-03-22T13:54:00.000+00:002017-11-07T19:21:35.759+00:0024. The Hidden Danger in your Diet Soda <br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjB7FpzTTj_nMkIvo_8kyd6rhd5ir9GKHCFcLeSM44JshQvmYsxfE8J5qHvhFE5Ro2zGv2klG2bOTh7v2F6LZ37nnpIg1ZAo_2tyJVP8mWTFEwRnYsVMpvvy6Dx4Tl0OMEBO3EYpBpS5ck/s1600/diet-soda-400x400.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjB7FpzTTj_nMkIvo_8kyd6rhd5ir9GKHCFcLeSM44JshQvmYsxfE8J5qHvhFE5Ro2zGv2klG2bOTh7v2F6LZ37nnpIg1ZAo_2tyJVP8mWTFEwRnYsVMpvvy6Dx4Tl0OMEBO3EYpBpS5ck/s320/diet-soda-400x400.jpg" width="320" /></a></div>
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A look at your local supermarket shelves stocked with row upon row of diet sodas and special offers will show you that you are invited to believe that a diet soda with artificial sweeteners is a ‘healthier’ option for you and your children than one packed with sugar. </div>
<div style="text-align: justify;">
Far too many recent research studies have shown that artificial sweeteners are very, very dangerous for your health. This doesn’t make sugary sodas better, it only means you are choosing from two evils, neither of which are good.</div>
<div style="text-align: justify;">
Non-caloric artificial sweeteners are one of the most commonly used food additives. Although numerous studies have given rise to concern about these, many people still steadfastly believe that artificial sweeteners are safe to consume. Recent studies in 2015 have found however that their consumption can lead to multiple health ailments, including, surprisingly, obesity, high blood pressure, heart disease, gout, diabetes, and cancer, (particularly lymphomas and leukaemia).</div>
<div style="text-align: justify;">
Almost all diet sodas today use aspartame, which is sold under brand names such as Equal or Nutrasweet. Aspartame is made up of not one, but three chemicals: methanol, aspartic acid, and phenylalanine. Cancer cells love an acidic environment where the cells are not getting sufficient oxygen or nutrients. Aspartame does all this and more. As well as being a possible cancer conduit, it has been shown to cause birth defects, brain damage and mood disorders. It can lead to serious changes in your serotonin levels, which leads to depression, behavioural and other emotional problems. </div>
<div style="text-align: justify;">
Speaking of brain damage, methanol, one of the main ingredients in aspartame, turns into formaldehyde, which is used to embalm deceased persons and preserve organs and species for clinical studies. This collects in certain parts of the brain, causing degenerative diseases such as ALS, Parkinson’s, and Alzheimers. </div>
<div style="text-align: justify;">
Adult Studies have shown that drinking three or more diet sodas a day is potentially more dangerous than smoking one pack of cigarettes per day. There appear to be no similar child studies. But it is surely reasonable to conclude that a smaller daily intake of diet ‘fizzies’ by a child will be equally as dangerous.</div>
<div style="text-align: justify;">
Diet sodas have far fewer chemicals than cigarettes, but over indulgence in aspartame-filled diet sodas will literally choke your cells, mutate your DNA, and possibly cause cancerous tumours in you and your child. </div>
<div style="text-align: justify;">
So when you buy a diet soda check the small print and find one that doesn’t contain aspartame. And while you are about it, check the ingredients listing of packaged deserts, ice cream and frozen fruit pops, hard candy and chewing gum, ketchup and jellies for aspartame used by the manufacturer as a sugar substitute. With governmental pressure on soda manufacturers to reduce sugar content by taxing it, the list of products containing aspartame as an alternative sweetener will grow - until it is outlawed as a food additive.</div>
<div style="text-align: justify;">
<br /></div>
<b>Further Reading</b><br />
<a href="http://naturalon.com/which-is-the-most-deadly-gmos-cigarettes-or-diet-soda/">Natural Health News </a> The danger of aspartame<br />
<a href="http://www.livestrong.com/article/389334-a-list-of-foods-containing-aspartame/">Livestrong</a> A list of foods containing aspartame<br />
<a href="http://www.health.com/health/gallery/0,,20739512,00.html">Health</a> 10 reasons why you should give up Diet Soda<br />
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-71511062652009566032016-03-15T11:07:00.000+00:002017-11-07T23:53:23.101+00:0023. What is the Cancer risk from processed and red meat?<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhQBZdM29Tw-76eNcGHk-hpyJoEklv_MGec6eNn-2HWoe5kWb-3BZAe8RZBQb82CgEf3B_bDnPRYVG-Z5aDSP3gH1ZPbWmBMX_heMidll4rTaHe2DV71diiw0py3fGia3KOY6MyCYG5WJ4/s1600/Processed+Meats+.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="236" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhQBZdM29Tw-76eNcGHk-hpyJoEklv_MGec6eNn-2HWoe5kWb-3BZAe8RZBQb82CgEf3B_bDnPRYVG-Z5aDSP3gH1ZPbWmBMX_heMidll4rTaHe2DV71diiw0py3fGia3KOY6MyCYG5WJ4/s400/Processed+Meats+.jpg" width="400" /></a></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> As I reported last year on two occasions in this blog, the World Health
Organization has made some serious charges that some of our favourite foods lead
to cancer risk. Processed meat was classified as a carcinogen, something that
causes cancer. And red meat was classified as a probable carcinogen that could lead to cancer. <o:p></o:p></span></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> Processed meat
includes hot dogs, ham, bacon, sausage, and some deli meats. It refers to meat
that has been treated in some way to preserve or flavour it. Processes include
salting, curing, fermenting, and smoking. Red meat includes beef, pork, lamb,
and goat.<o:p></o:p></span></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> Twenty-two experts
from 10 countries reviewed more than 800 studies to reach their conclusions.
They found that eating 50 grams of processed meat every day increased the risk
of colorectal cancer by 18%. That’s the equivalent of about 4 strips of bacon
or 1 hot dog. For red meat, there was evidence of increased risk of colorectal,
pancreatic, and prostate cancer.<o:p></o:p></span></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> Overall, the lifetime
risk of someone developing colon cancer is 5%. To put the numbers into
perspective, the increased risk from eating the amount of processed meat in the
study would raise average lifetime risk to almost 6%.<o:p></o:p></span></div>
</div>
<div style="-webkit-text-stroke-width: 0px; mso-line-height-alt: 13.5pt; orphans: auto; text-align: -webkit-left; widows: 1; word-spacing: 0px;">
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> Colleen Doyle,
American Cancer Society managing director of nutrition and physical activity,
says, “We should be limiting red and processed meat to help reduce colon cancer
risk, and possibly, the risk of other cancers. The occasional hot dog or
hamburger is OK.”<o:p></o:p></span></div>
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<div style="text-align: justify;">
<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"> Nutritionists have long
recommended a diet that limits processed meat and red meat, and that is high in
vegetables, fruits, and whole grains, (see my blog No.12 Mediterranean Diet cuts uterine cancer risk). They<span class="apple-converted-space"> </span>recommend
choosing fish, poultry, or beans instead of red meat and processed meat. And to refine this further, I suggest <i>wild </i>as opposed to <i>farmed</i> fish, and <i>free range </i>poultry.<o:p></o:p></span></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"><b><br /></b></span></div>
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<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"><b>Further Reading</b></span></div>
<div style="-webkit-text-stroke-width: 0px; mso-line-height-alt: 13.5pt; orphans: auto; text-align: -webkit-left; widows: 1; word-spacing: 0px;">
<span style="color: #242d3a; font-family: "arial"; font-size: 14.0pt;"><b><a href="http://www.pnas.org/content/112/2/542.abstract">National Academy of Sciences, USA.</a> </b>Red meat and Cancer progression.</span></div>
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-85703290417314103412016-03-14T14:48:00.004+00:002017-11-07T23:59:27.512+00:0022. Cancer treatment through Immunotherapy<div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgD32jTell5qJqcuZguaA0xJx4RS11IZjw3ppvAxiymJj_x_Z2TD4R6E5G7QE4NZbZXygQWSAL2ueEnSpbBytS1HIVweSmkO98WcozG_BEqPKWkmcZp4ss6iWBxn6yFpKrxvYiaMoADJlc/s1600/cancer+cell.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="270" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgD32jTell5qJqcuZguaA0xJx4RS11IZjw3ppvAxiymJj_x_Z2TD4R6E5G7QE4NZbZXygQWSAL2ueEnSpbBytS1HIVweSmkO98WcozG_BEqPKWkmcZp4ss6iWBxn6yFpKrxvYiaMoADJlc/s400/cancer+cell.jpg" width="400" /></a></div>
<div style="text-align: center;">
<i><span style="font-size: x-small;">Photo: MedicineNet.com</span></i></div>
<br />
<div style="text-align: justify;">
Laboratory research into the genetic makeup of cancer tumours is showing the possibility of a new approach to a treatment that delivers potent therapies specifically tailored to individual patients.</div>
<div style="text-align: justify;">
Science Magazine has published an article on the work of an international team of research scientists from Harvard, MIT and University College London. They found that even as cancer tumours grow and spread around the body, they carry with them a number of biological protein “flags” that the immune system could be primed to attack.</div>
<div style="text-align: justify;">
Because these flags are found only on cancer cells, they could provide unique targets for possible new therapies. Such therapies would draw on the power of the immune system to recognise the protein flags and destroy the cancer cells with a precision attack.</div>
<div style="text-align: justify;">
A major obstacle to this type treatment is that tumours manage to switch off the cells of the immune system. Many laboratories across the globe are now learning how to combat this by reactivating the immune system to destroy the cancer. </div>
<div style="text-align: justify;">
I asked Dr. Ian Hampson, Professor in Viral Oncology at the University of Manchester Institute of Cancer Studies, to comment on such an approach which, if successful, could revolutionise cancer treatment.</div>
<div style="text-align: justify;">
<br /></div>
<div style="text-align: right;">
<b>Ian MacWatt</b></div>
<br />
<i><b>Dr. Ian Hampson writes: </b></i><br />
<div style="text-align: justify;">
The problem is that this type of precision attack therapy relies on the isolation of immune cells from every individual patient’s tumour. These are then grown in the laboratory to provide large numbers of cells and they can also even be genetically altered so that they target the tumour more effectively. Finally they are transfused back into the patient where they attack and destroy the cancer. </div>
<div style="text-align: justify;">
To illustrate, it is well known that cells from one person cannot be transfused into another who is not tissue type compatible. This is why immune cells from one patient’s tumour cannot be used to treat another. In order to get round this problem scientists are working to engineer immune cells which can be used to target tumours in any person regardless of tissue type; a sort of group ‘O’ universal donor immune cell which could then be modified to target many types of tumour in different people.</div>
<div style="text-align: justify;">
This would mean that large stocks of such cells could be produced and stored for use whenever needed to treat different patients, which would vastly reduce the cost of this type of therapy. </div>
<div style="text-align: justify;">
It is very clear that this approach will provide precision weapons to fight cancer which are far less damaging to the patient than blanket chemotherapy, which not only destroys the cancer cells but can also damage the patient’s immune system. However, if this new approach sounds expensive, that’s because it is, although there may be some light at the end of this long tunnel.</div>
<br />
<br /></div>
Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-23807053866042866072016-02-16T20:00:00.000+00:002017-11-08T00:06:54.035+00:0021. Clinical evidence for cancer prevention through diet<div dir="ltr" style="text-align: left;" trbidi="on">
<div class="MsoNoSpacing" style="text-align: justify; text-justify: inter-ideograph;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="background: white;"><br /></span></b></div>
<div class="MsoNoSpacing" style="text-align: center;">
<b><span lang="EN-US" style="background: white;"><br /></span></b></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi-KLDOrimchpJcvoc4OMYe_dIf7re5q21BgPKRB_A_mpJ7hCPJLQC9lN6O0w18uFHUy9ADdktU5sfQtt4KHE-wQQikqaIcCcRqtiuxPn3d0oKf-m3xI2pzVJqHyaGNUEEXR3YPW_cA6DI/s1600/mediterraneandiet-intro-400x400.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi-KLDOrimchpJcvoc4OMYe_dIf7re5q21BgPKRB_A_mpJ7hCPJLQC9lN6O0w18uFHUy9ADdktU5sfQtt4KHE-wQQikqaIcCcRqtiuxPn3d0oKf-m3xI2pzVJqHyaGNUEEXR3YPW_cA6DI/s320/mediterraneandiet-intro-400x400.jpg" width="320" /></a></div>
<div class="MsoNoSpacing" style="text-align: center;">
<br /></div>
<div class="MsoNoSpacing">
<span lang="EN-US" style="background: white;"><span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="background: white;"> Findings from
an Italian study published this month in the American Journal of Nutrition has
demonstrated a clear link between the amount of</span><span class="apple-converted-space"><span lang="EN-US" style="background: white; color: black; font-family: "arial";"> phytochemical-rich
</span></span><span lang="EN-US" style="background: white;">polyphenols</span><span class="apple-converted-space"><span lang="EN-US" style="background: white; color: black; font-family: "arial";"> </span></span><span lang="EN-US" style="background: white;">we eat and mortality from breast,
pancreatic, throat, prostate and skin cancers. Phytochemicals are plant
compounds, which give vegetables and fruit their pleasing colour, taste and
aroma.<o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="background: white;"><span style="mso-spacerun: yes;"> </span>Over 12 years, the joint
Italian/Spanish/USA study assessed intake in 807 men and women by measuring
their total urinary polyphenol, which could have come from numerous phytochemical-rich
polyphenol food sources including tomatoes, tea, broccoli, herbs and spices or
even Chianti wine. It showed that those with the highest polyphenol levels had
the lowest death rate from cancer and heart disease.<o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<span lang="EN-US" style="color: #474747;"><span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
<div class="MsoNoSpacing" style="text-align: center;">
<br /></div>
<div class="MsoNoSpacing" style="text-align: center;">
<b style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="color: #474747;">Clinical evidence for a dietary benefit after cancer<o:p></o:p></span></b></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="color: #474747;"><span style="mso-spacerun: yes;"> </span>Other studies published by the British
Journal of Medical Practitioners have shown that the anti-cancer effects of phytochemicals
in these polyphenols do not stop after a diagnosis of cancer when combined with
other healthy lifestyle habits such as regular exercise. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="color: #474747;"><span style="mso-spacerun: yes;"> </span>Breast cancer survivors eating polyphenol
fruit, vegetables, soy and green tea were found to have lower relapse rates. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="color: #474747;"><span style="mso-spacerun: yes;"> </span>Individuals with skin cancer, who had a
high intake of leafy green vegetables and broccoli, had lower rates of new
cancer formation, while a polyphenol rich diet has been linked to a slower rate
of PSA progression among men with indolent prostate cancer.<o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span lang="EN-US" style="color: #474747;"><span style="mso-spacerun: yes;"> </span>A Shanghai Breast Cancer Survival Study
has shown a dramatic drop in relapse and death for breast, chronic leukaemia
and prostate cancer sufferers with high intake of polyphenols.<span style="mso-spacerun: yes;"> </span></span><span style="background: white; color: #474747;">Cancer cells have to go through a series of
biochemical pathways in order to grow faster, invade adjacent organs and
metastasise. <o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="background: white; color: #474747;"><span style="mso-spacerun: yes;"> </span>Laboratory experiments using
cancer and normal cells in petri dishes show that some foods can directly
inhibit these pathways. <span style="mso-spacerun: yes;"> </span>Polyphenols have
a direct Stop Cancer mechanism of action via inflammation cellular modulation
and signalling events involved in growth, invasion and metastasis.<span style="mso-spacerun: yes;"> </span><o:p></o:p></span></div>
</div>
<div class="MsoNoSpacing">
<div style="text-align: justify;">
<span style="background: white; color: #474747;"><span style="mso-spacerun: yes;"> </span>I strongly recommend reading
the BJMP article below. Essential reading, it not only gives a summary of the recent studies but
also provides a comprehensive list of phytochemicals with notable food rich
sources in a variety of fruits, vegetables, grains, pulses and nuts. </span><b><span style="color: #474747; mso-ansi-language: EN-GB;"><o:p></o:p></span></b></div>
<div style="text-align: right;">
<span style="background: white; color: #474747;"><b>Ian MacWatt</b></span></div>
</div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
<b style="mso-bidi-font-weight: normal;"><span style="background: white; color: #474747;">Further Reading</span></b></div>
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<b style="mso-bidi-font-weight: normal;"><span style="background: white; color: #474747;"><a href="http://files.ctctcdn.com/e241e800101/eac3ade0-f6dc-4219-a5a5-99e72854334e.pdf">British
Journal of Medical Practitioners</a> : </span></b><span style="background: white; color: #474747;">Phytochemicals in Polyphenols and
cancer prevention </span><span lang="EN-US"><o:p></o:p></span></div>
<div class="MsoNoSpacing">
<span style="background: white; color: #474747;"><b><a href="http://www.stuartskitchen.blogspot.com/">Stuart's Kitchen</a> : </b>Recipes for healthy seasonal Mediterranean Diet produce. </span></div>
</div>
Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-84277946165205905312016-01-20T10:03:00.002+00:002017-11-08T00:15:55.704+00:0020. Obesity and Cancer: New Moves in UK<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhy30BeHXQRSBNf5IYNL-wQX6EEKBEhxGKSmaINC2a7y_LOeUXasvR4e6XpIn7pVqMO2BeJCeiYZ_ShuXXVhrFdJ5LcWuOkfxtac9YI5xdt1R65gv7EUnPq2c-1Ouy4UPSAFeJMYp11ZHg/s1600/images.jpeg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="396" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhy30BeHXQRSBNf5IYNL-wQX6EEKBEhxGKSmaINC2a7y_LOeUXasvR4e6XpIn7pVqMO2BeJCeiYZ_ShuXXVhrFdJ5LcWuOkfxtac9YI5xdt1R65gv7EUnPq2c-1Ouy4UPSAFeJMYp11ZHg/s640/images.jpeg" width="640" /></a></div>
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Bad diet has recently overtaken smoking as the biggest single cause of the 40% of lifestyle-linked avoidable illness the service treats. Simon Stevens, chief executive of NHS England has said. He added: “Smoking still kills 80,000-plus people a year, smoking is still a huge problem. But it turns out that diet has edged ahead.” </div>
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His comment came as he announced the introduction of a sugar tax on high sugar drinks and snacks sold in hospital cafes and vending machines to help tackle the “national sugar high”. Sugar addiction is increasingly ruining children's and adults' health through obesity, itself a station on the direct line to a number of cancers.</div>
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Simon Stevens also upped the stakes in TV Chef Jamie Oliver’s campaign to bring in a sugar tax by urging ministers to take radical action against obesity, including forcing food firms to strip sugar out of their products, as part of an unprecedented assault on bad diet.Obesity is known to be associated with increased risks of the following cancer types, and possibly others as well:</div>
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Esophagus (throat)<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Pancreas<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Colon and rectum<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Breast (after menopause)<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Endometrium (lining of the uterus)<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Kidney<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Thyroid<br />
•<span class="Apple-tab-span" style="white-space: pre;"> </span>Gallbladder<br />
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Studies in USA have shown a direct link between obesity and cancer. The percentage of cases attributed to obesity varied widely for different cancer types but was as high as 40 % for some cancers, particularly uterine cancer and esophageal adenocarcinoma, (throat cancer to you and me).</div>
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A projection of the future health and economic burden of obesity in 2030 estimated that continuation of existing trends in obesity will lead to about 500,000 additional cases of cancer in the United States by 2030. This analysis also found that if every adult reduced their weight by roughly 1 kg (or 2.2 lbs) for an adult of average weight, this would prevent the increase in the number of cancer cases and actually result in the avoidance of about 100,000 new cases of cancer.</div>
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While these figures relate to US studies, a similar pattern has emerged in the UK. Cancer prevention through appropriate lifestyle and diet choices is always a better, and safer, option than contracting life-threatening cancer, lengthy 'slash, burn and poison' (invasive surgery, radiography and chemotherapy) treatment and possible cure.</div>
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Further Reading<br />
<a href="http://www.examiner.com/article/sugar-and-its-role-cancer-why-americans-better-pay-attention">Examiner </a> Sugar, Obesity and Cancer Risk<br />
<a href="http://www.medicalnewstoday.com/articles/254974.php?sr">Medical News Today</a> How quitting sugar impacts onbody weight<br />
<a href="http://www.theguardian.com/society/2016/jan/17/nhs-sugar-tax-hospitals-tackle-uk-obesity-crisis-simon-stevens">Guardian</a> NHS and need for sugar tax<br />
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Anonymoushttp://www.blogger.com/profile/04928093918579542907noreply@blogger.com0tag:blogger.com,1999:blog-2067211831338877533.post-51024311201061756282015-12-15T12:45:00.001+00:002017-11-07T19:29:44.471+00:0019. Chemo, Superbugs and Diet<div style="background-color: white; color: #4a4a4a; font-family: Roboto, sans-serif; font-size: 15px; line-height: 22px; margin-bottom: 25px;">
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The ultimate superbug that is resistant to the ultimate antibiotic has reached Europe in an apparently inexorable global spread from China.</div>
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In November the medical journal <em>Lancet Infectious Diseases </em>reported that researchers in China had discovered bacteria with a dangerous new antibiotic-resistance gene that is spreading from livestock to people in China. This newly identified gene, called MCR-1, is on a mobile piece of DNA known as a plasmid that can copy itself and jump from bacterium to bacterium, spreading antibiotic resistance; the modern superbug.</div>
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Mobile resistance genes spread quickly in the modern world of global traffic; riding in people, animals, and food across continents. MCR-1 bestows resistance to the antibiotic colistin<strong>,</strong> which, although it has been around for 50 years, is considered the last drug available to treat some deadly infections. It actually fell out of favour due to kidney toxicity and was largely replaced by aminoglycoside antibiotics such a streptomycin, which might explain why it is still effective.</div>
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Colistin is used extensively in animal agriculture in China, where this superbug first appeared and made its jump from animals to humans, and has now been found on a person in Denmark. <br />
Colistin is also approved for use in factory farming in the European Union and unless action is taking quickly to ban the indiscriminate use of it and other antibiotics in animal agriculture and aquaculture, our livestock production facilities will become breeding grounds for colistin resistant and other multidrug resistant bacteria that will inevitably enter into our food supply and humans.</div>
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Antibiotics such as colistin are essential infection suppressors in chemotherapy treatment, which indiscriminately kills not only cancer cells but also the patient’s immune system. If we cannot contain the spread of bacteria resistant to colistin, and other antibiotics, we could face increasing numbers of untreatable infections afflicting cancer patients at a time when they are at their most vulnerable. Transplant patients taking immuno-suppressant anti-rejection drugs are equally at risk.</div>
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That being said, we need to concentrate on four things to stop cancer: cancer prevention, research into effective treatment for pre-cancerous states, seek alternative cures to chemotherapy, and make more sensible use of our available antibiotic arsenal</div>
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There is some movement in this direction:</div>
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<strong>Prevention:</strong> There is a growing understanding of the importance of lifestyle and diet on prevention of a number of cancers, as advocated in this blog. Carcinogenic pesticides are now understood to cause inflammation leading to cancers such as bowel cancer when introduced into the human food chain via animal feed. There is a growing awareness of the effects of pesticides on our health and increasing demand for Non-GMO and organic food in our shops and supermarkets.</div>
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<strong>Treatment:</strong> As noted elsewhere under <a href="http://caringcancertrust.com/cancer-research/cervical-cancer-breakthrough/">Research</a>, the University of Manchester Viral Oncology Research Laboratories announce encouraging research results into an effective answer to cervical cancer at its treatable pre-cancerous stage.</div>
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<strong>Cure:</strong> Associated US companies AddVie and J & J have just announced excellent trial results for a new drug that significantly reduces death risk and disease progression vs chemotherapy in late stage leukaemia patients.</div>
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<strong>Further Reading</strong><strong> </strong></div>
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<span style="background-color: transparent; line-height: 22px;"><span style="color: #4a4a4a; font-family: "times" , "times new roman" , serif; font-size: xx-small;"><b><a href="http://www.genewatch.org/sub-568547">Gene Watch</a> </b>GM crops and foods in Europe and UK. </span></span></div>
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<span style="background-color: transparent; line-height: 22px;"><span style="color: #4a4a4a; font-family: "times" , "times new roman" , serif; font-size: xx-small;"><a href="http://www.gmfreeze.org/why-freeze/unwanted/where-buy-non-gm-fed/"><b>GM Freeze</b></a> Where to buy non-GM fed animal produce UK.</span></span></div>
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<span style="background-color: transparent; line-height: 22px;"><span style="color: #4a4a4a; font-family: "times" , "times new roman" , serif; font-size: xx-small;"><a href="http://www.nongmoshoppingguide.com/index.html"><b>Non-GMO Shopping Guide</b></a> USA Listing.</span></span></div>
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<span style="background-color: transparent; line-height: 22px;"><span style="color: #4a4a4a; font-family: "times" , "times new roman" , serif; font-size: xx-small;"><b><a href="http://www.soilassociation.org/news/newsstory/articleid/8614/organic-news-antibiotics-farm-animals-and-the-need-for-change">Soil Association</a> </b>Anti-biotics, farm animals and the need for change.</span></span></div>
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<span style="font-family: "times" , "times new roman" , serif; font-size: xx-small;"><strong style="color: #3783c1; outline: none; transition: color 0.4s;"><a href="http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00463-6/abstract">The Lancet Infectious Diseases</a> : </strong>Colistin resistance: a major breach in our last line of defence.</span></div>
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<span style="font-family: "times" , "times new roman" , serif; font-size: xx-small;"><strong><a href="http://breastcancer.org/">Breastcancer.org</a> : </strong>How Chemotherapy Affects the Immune System.</span></div>
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<span style="font-family: "times" , "times new roman" , serif; font-size: xx-small;"><strong><a href="http://www.manchester.ac.uk/discover/news/hiv-drug-used-to-reverse-effects-of-virus-that-causes-cervical-cancer">Manchester 1824</a> : </strong>HIV Drug used to reverse effects of virus that causes cervical cancer.</span></div>
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<span style="font-family: "times" , "times new roman" , serif; font-size: xx-small;"><strong><a href="http://www.reuters.com/article/us-health-blood-johnson-johnson-idUSKBN0TP0KY20151206#HetKIvEWfsecH8W5.97">Reuters </a> </strong>Trials Drug cuts death risk vs chemo.</span></div>
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